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Interoperability Proving Ground (IPG) submissions within the ONC Tech Lab are submitted by healthcare, technology and development organizations that are invested in Health IT and Interoperability and want to share, learn and collaborate with similar stakeholders in the US, and around the world.

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Sync for Genes Phase 2 Pilot - Lehigh Valley Health Network (LVHN)

The primary LVHN genomics focus is to fully integrate relevant genomic sequencing results into structured data fields in the EHR, and by creating this more advanced foundation of genomic/phenotype data, enable the ability to rapidly add real-time pharmacogenomics clinical decision support to other types of care. This will support clinical orders, clinical documentation, and EHR alerts and allow LVHN to assess if various medication orders could be supported with pharmacogenomics tools accessing genomic sequencing results. LVHN also attempted to address the receipt and access to the basic genomic sequencing results (VCF, BAM, CRAM files) by creating a database / repository to hold these files and link them to the EHR as LVHN has done with clinical PACS systems. 

With respect to pharmacogenomics LVHN reviewed FDA data on genetic implications to develop a list of medications to include. LVHN used other factors such as cost avoidance to determine what medications would be part of the pilot. In learning how to set up the EHR LVHN determined medications should be pared with appropriate genomic test. LVHN reported that ordering physicians have skepticism on pharmacogenomics and would like to have increased education and support for providers.
Start Date
Projected End Date
Project Tags
  • All of Us
  • Clinical Genomics
  • EHR
  • FHIR
  • genomics
  • HL7
  • interoperability
  • NGS
  • NIH
  • ONC
  • ONC-led
  • Pharmacogenomics
  • PMI
  • Precision Medicine
  • Sync For Genes
Project Point of Contact:
Project Results
To provide actionable feedback to the HL7® Clinical Genomics Work Group (CG WG) and advance the maturity of FHIR® Genomics, Sync for Genes Phase 2 engaged four unique pilot sites implementing the current FHIR® Genomics profiles in Standard for Trial Use (STU) 3. To help advance the maturity level of selected FHIR genomics resources, pilot sites were also encouraged to actively participate in and provide feedback directly to the CG WG. Feedback to the CG WG from the pilot sites on STU 3 implementations, in turn, support the development of the FHIR® specifications in Draft STU 4, which is not currently supported in EHRs. Pilot sites also participated in the Sync 4 Genes Scenario under the Clinical Genomics Track at the January 2019 HL7® Connectathon to further support the development of the FHIR® Genomics specification in Draft STU 4. The goal was to demonstrate connectivity and exchange of clinical genomic data using the FHIR® Genomics specification within an EHR.