Important update: Healthcare facilities
CDC has updated select ways to operate healthcare systems effectively in response to COVID-19 vaccination. Learn more
Given new evidence on the B.1.617.2 (Delta) variant, CDC has updated the guidance for fully vaccinated people. CDC recommends universal indoor masking for all teachers, staff, students, and visitors to K-12 schools, regardless of vaccination status. Children should return to full-time in-person learning in the fall with layered prevention strategies in place.
The White House announced that vaccines will be required for international travelers coming into the United States, with an effective date of November 8, 2021. For purposes of entry into the United States, vaccines accepted will include FDA approved or authorized and WHO Emergency Use Listing vaccines. More information is available here.
Travel requirements to enter the United States are changing, starting November 8, 2021. More information is available here.

Clinical Care Information for COVID-19

Clinical Care Information for COVID-19
Updated Apr. 29, 2022

Clinical Care Guidance

Clinical information on patients with COVID-19, including:

  • Clinical presentation and course
  • Lab and radiographic findings

Ending Isolation

When COVID-19 patients can be around others if the patient is:

  • With symptoms
  • Without symptoms
  • Immunocompromised

Managing COVID-19 Patients


The National Institutes of Health (NIH) provides treatment and management recommendations for COVID-19 patients. Their treatment guidelines are updated regularly based on new data.

COVID-19 Preventive Medication

Patients who are moderately or severely immunocompromised or severely allergic to COVID-19 vaccines, may be eligible for Evusheldexternal icon, that can help prevent them from getting COVID-19.  It is given as 2 injections.

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The COVID-19 Phone Advice Line Tool pdf icon[424 KB, 20 pages] helps healthcare personnel give advice on appropriate medical care for children or adults with possible COVID-19.

Guidance by Patient Type

Multisystem Inflammatory Syndrome in Children

Healthcare providers who have cared or are caring for patients younger than 21 years of age meeting criteria for multisystem inflammatory syndrome in children (MIS-C) should report suspected cases to their local, state, or territorial health department.

For additional reporting questions, please contact CDC’s 24-hour Emergency Operations Center at 770-488-7100.