Director, Division of Biochemical Toxicology

Frederick A. Beland, Ph.D.
(870) 543-7121
[email protected] 

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 About  |  Publications  |  Division Scientists

Background

Frederick A. Beland received a B.A. degree in biology from The Colorado College, and M.S. and Ph.D. degrees in chemistry from Montana State University. Following postdoctoral work in the Ben May Laboratory at the University of Chicago, he was recruited by NCTR to continue his studies in cancer research. These studies, which are funded primarily by FDA/NCTR and the National Institute of Environmental Health Sciences/National Toxicology Program, have resulted in over 350 publications.

Dr. Beland is an elected member of the American and European Associations for Cancer Research and the American Chemical Society. He has served on the program committee for the American Association for Cancer Research, on the Board of Directors for the Division of Chemical Toxicology, American Chemical Society, and as a member of the American Cancer Society and National Institutes of Health study sections. He has been a member of the International Agency for Research on cancer working groups to evaluate the carcinogenic risks to humans. He is the past editor of Cancer Letters, is currently a member of the editorial board for BMC Cancer, and has served as a reviewer for more than 30 scientific journals.
 

Research Interests

The focus of Dr. Beland's research has been to assess the carcinogenic potential of chemicals of interest to FDA and to understand the mechanisms responsible for the carcinogenic response. These investigations involve conducting chronic bioassays in experimental animals and conducting in vitro and in vivo mechanistic studies to determine if the responses observed in experimental animals are relevant to humans. An important component of these studies is the elucidation of dose-response relationships that can be used to guide risk assessments. Recent studies have focused on acrylamide, furan, anti-retroviral drugs (e.g., zidovudine and nevirapine), and inorganic arsenic.

Professional Societies/National and International Groups

American Association for Cancer Research
Member
1977 - Present

American Chemical Society (ACS)
Member
2000 - Present

BMC Cancer
Member, Editorial Board
2004 - Present

Chemical Research in Toxicology, ACS
Member, Editorial Board
2014 - 2017

Chemical Toxicology Division, ACS
Councilor
2014 - 2017

Environmental Protection Agency (EPA)
Member, EPA Science Advisory Board Panel on Trimethylbenzenes
2014

European Association for Cancer Research
Member
1983 - Present

Food and Agriculture Organization of the United Nations (FAO) and the World Health
Organization (WHO)
Member, Expert Roster, Joint FAO/WHO Expert Committee on Food Additives (JEFCA)
2016 - Present

International Agency for Research on Cancer (IARC)
Member, IARC Working Group on Tumor Concordance and Mechanisms
2012 - 2016

Member, IARC Working Group to Evaluate the Carcinogenic Risks to Humans. Some Drugs and
Herbal Products
2013

Member, IARC Working Group to Evaluate the Carcinogenic Risks to Humans. Consumption of
Red Meat and Processed Meat.
Chairman, Experimental Carcinogenesis Section
2015

Member, IARC Working Group to Evaluate the Carcinogenic Risks to Humans. Some Chemicals in Food
and Consumer Products.
Chairman, Mechanistic and Other Relevant Data Section
2016-2017 

Selected Publications

Application of the Key Characteristics of Carcinogens in Cancer Hazard Identification.
Guyton K., Rusyn I., Chiu W., Corpet D., Van den Berg M., Ross M., Christiani D., Beland F. and Smith M.
Carcinogenesis. 2018 Apr 5, 39(4):614-622. 0

Metabolism and Disposition of Arsenic Species After Repeated Oral Dosing with Sodium Arsenite in Drinking Water. II. Measurements in Pregnant and Fetal CD-1 Mice.
Twaddle N., Vanlandingham M., Beland F. and Doerge D.
Food Chem Toxicol. 2018 May, 115:178-184. 

Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells.
Dreval K., Tryndyak V., Kindrat I., Twaddle N., Orisakwe O., Mudalige T., Beland F., Doerge D. and Pogribny I.
Toxicol Sci. 2018 Apr 1, 162(2):676-687. 

MicroRNA Deregulation in Nonalcoholic Steatohepatitis-Associated Liver Carcinogenesis.
de Conti A., Ortega J., Tryndyak V., Dreval K., Moreno F., Rusyn I., Beland F. and Pogribny I.
Oncotarget. 2017 Aug 1, 8(51):88517-88528. 

Epigenetically Mediated Inhibition of S-Adenosylhomocysteine Hydrolase and the Associated Dysregulation of 1-Carbon Metabolism in Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
Pogribny I., Dreval K., Kindrat I., Melnyk S., Jimenez L., de Conti A., Tryndyak V., Pogribna M., Ortega J., James S., Rusyn I. and Beland F.
FASEB J. 2018 Mar, 32(3):1591-1601. 

Effect of Methapyrilene Hydrochloride on Hepatic Intracellular Iron Metabolism In Vivo and In Vitro.
Kindrat I., Dreval K., Shpyleva S., Tryndyak V., de Conti A., Mudalige T., Chen T., Erstenyuk A., Beland F. and Pogribny I.
Toxicol Lett. 2017 Nov 5, 281:65-73.

The Role of Epigenomic Alterations in Furan-Induced Hepatobiliary Pathologies.
de Conti A., Beland F. and Pogribny I.
Food Chem Toxicol. 2017 Nov, 109(Pt 1):677-682.

Aloin, A Component of the Aloe Vera Plant Leaf, Induces Pathological Changes and Modulates the Composition of Microbiota in the Large Intestines of F344/N Male Rats.
Boudreau M., Olson G., Tryndyak V., Bryant M., Felton R. and Beland F.
Toxicol Sci. 2017 Aug 1, 158(2):302-318..

Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis is Associated with Histone H4 Lysine 16 Deacetylation.
de Conti A., Dreval K., Tryndyak V., Orisakwe O., Ross S., Beland F. and Pogribny I.
Mol Cancer Res. 2017 Sep, 15(9):1163-1172.

MIR-1247 Blocks SOX9-Mediated Regeneration in Alcohol- and Fibrosis-Associated Acute Kidney Injury in Mice.
Dreval K., de Conti A., Furuya S., Beland F., Rusyn I. and Pogribny I.
Toxicology. 2017 Jun 1, 384:40-49.

Photo-Co-Carcinogenesis of Topically Applied Retinyl Palmitate in SKH-1 Hairless Mice.
Boudreau M., Beland F., Felton R., Fu P., Howard P., Mellick P., Thorn B. and Olson G.
Photochem Photobiol. 2017 Jul, 93(4):1096-1114.

Detection of Pyrrolizidine Alkaloid DNA Adducts in Livers of Cattle Poisoned with Heliotropium europaeum.
Fu P., Xia Q., He X., Barel S., Edery N., Beland F. and Shimshoni J.
Chem Res Toxicol. 2017 Mar 20, 30(3):851-858.

Organ-Specific Epigenetic Changes Induced by the Nongenotoxic Liver Carcinogen Methapyrilene in Fischer 344 Rats.
Shpyleva S., Dreval K., de Conti A., Kindrat I., Melnyk S., Yan J., Chen T., Beland F. and Pogribny I.
Toxicol Sci. 2017 Mar 1, 156(1):190-198.

Cytochrome P450-Mediated Metabolism of Triclosan Attenuates its Cytotoxicity in Hepatic Cells.
Wu Y., Chitranshi P., Loukotková L., Gamboa da Costa G., Beland F., Zhang J. and Fang J.
Arch Toxicol. 2017 Jun, 91(6):2405-2423.

Low Dose Assessment of the Carcinogenicity of Furan in Male F344/N NCTR Rats in a 2-Year Gavage Study.
Von Tungeln L., Walker N., Olson G., Mendoza M., Felton R., Thorn B., Marques M., Pogribny I., Doerge D. and Beland F.
Food Chem Toxicol. 2017 Jan, 99:170-181.

New Insights into the Molecular Mechanisms of Chemical Carcinogenesis: In Vivo Adduction of Histone H2B by a Reactive Metabolite of the Chemical Carcinogen Furan.
Nunes J., Martins I., Charneira C., Pogribny I., de Conti A., Beland F., Marques M., Jacob C. and Antunes A.
Toxicol Lett. 2016 Dec 15, 264:106-113.

Division Scientists

Contact information for all lab members:
(870) 543-7391
[email protected] 
 
Matthew Bryant, Ph.D.
Lead Chemist
 
Luísa Camacho, Ph.D.
Sr. Staff Fellow
    
Kenneth Barry Delclos, Ph.D.
Research Pharmacologist  

Jia-Long Fang, Ph.D.
Research Biologist
 
Peter Fu, Ph.D.
Sr. Research Chemist 

Gonçalo Gamboa da Costa, Ph.D.
Sr. Staff Fellow  

Lei Guo, Ph.D.
Research Biologist
 
George Hammons, Ph.D.
Sr. Research Scientist  

Beverly Lyn-Cook, Ph.D.
Interdisciplinary Research Biologist 
 
Igor Pogribny, M.D., Ph.D.
Research Biologist  

William Tolleson, Ph.D.
Research Chemist