Staff Fellow, Division of Bioinformatics and Biostatistics

Dongying Li, Ph.D.
(870) 543-7121
NCTRResearch@fda.hhs.gov

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About  |  Publications

Background

Dr. Dongying Li received a Ph.D. in cell biology, stem cells and development from the University of Colorado Anschutz Medical Campus. She worked as a postdoctoral fellow at Tulane University. She then joined the Division of Bioinformatics and Biostatistics at FDA’s National Center for Toxicological Research (NCTR) as an Oak Ridge Institute for Science and Education fellow in 2017 and became a staff fellow in 2020. She has authored/co-authored over 20 peer-reviewed publications, including reviews, research articles, and book chapters.
 

Research Interests

Dr. Li’s research focuses on investigating epigenetic mechanisms that contribute to drug-induced liver injury and inter-individual differences in drug response. Specifically, she is interested in understanding the role of noncoding ribonucleic acids (RNAs), such as microRNAs and long noncoding RNAs, in regulating the expression of drug metabolizing enzymes, which are essential to drug efficacy and toxicity. Dr. Li is invested in leveraging big data and integrating computational, in vitro, and in vivo analyses to identify novel, actional biomarker candidates for early and accurate prediction of liver toxicity. Her research activities are highly in line with FDA’s priority in predictive toxicology and using alternative methods for toxicological studies.
 

Professional Societies/National and International Groups 

MidSouth Computational Biology and Bioinformatics Society
Member
2018 – Present

Society of Toxicology (SOT)
Member
2018 – Present

South Central Chapter, SOT
Secretary
2021 – Present

Selected Publications 

Characterization of Cytochrome P450s (CYP)-Overexpressing HepG2 Cells for Assessing Drug and Chemical-Induced Liver Toxicity.
Chen S., Wu Q., Li X., Li D., Mei N., Ning B., Puig M., Ren Z., Tolleson W.H., and Guo L.
J Environ Sci Health C Toxicol Carcinog. 2021, 39(1):68-86. doi: 10.1080/26896583.2021.1880242.

Biochemical Features and Mutations of Key Proteins in SARS-CoV-2 and Their Impacts on RNA Therapeutics.
Zeng L., Li D., Tong W., Shi T., and Ning B.
Biochem Pharmacol. 2021, 114424. doi:10.1016/j.bcp.2021.114424.
 
Impact of Sequencing Depth and Library Preparation on Toxicological Interpretation of RNA-seq Data in a “Three-Sample” Scenario.
Li D., Gong B., Xu J., Ning B., and Tong W.
Chem. Res. Toxicol. 2021, 34(2):529-540. doi: 10.1021/acs.chemrestox.0c00368. Epub 2020 Dec 23.

Identification of Translational MicroRNA Biomarker Candidates for Ketoconazole-Induced Liver Injury Using Next-Generation Sequencing.
Li D., Knox B., Gong B., Chen S., Guo L., Liu Z., Tong W., and Ning B.
Toxicol Sci. 2021, 179(1):31-43 doi:10.1093/toxsci/kfaa162.

Linking Pharmacogenomic Information on Drug Safety and Efficacy with Ethnic Minority Populations.
Li D., Xie A.H., Liu Z., Li D., Ning B., Thakkar S., Tong W., and Xu J. 
Pharmaceutics. 2020, 12, 1021. doi: 10.3390/pharmaceutics12111021.

Mitochondrial Dysfunction and Apoptosis Underlie the Hepatotoxicity of Perhexiline.
Ren Z., Chen S., Seo J., Guo X., Li D., Ning B., and Guo L.
Toxicol In Vitro. 2020, 69:104987. doi: 10.1016/j.tiv.2020.104987. Epub 2020 Aug 28.

The Role of Hepatic Cytochrome P450s in the Cytotoxicity of Sertraline.
Chen S., Wu Q., Li X., Li D., Fan M., Ren Z., Bryant M., Mei N., Ning B., and Guo L.
Arch Toxicol. 2020, 94(7):2401-2411. doi: 10.1007/s00204-020-02753-y. Epub 2020 May 5.

Long Noncoding RNA LINC00844-Mediated Molecular Network Regulates Expression of Drug Metabolizing Enzymes and Nuclear Receptors in Human Liver Cells.
Li D., Wu L., Knox B., Chen S., Tolleson W.H., Liu F., Yu D., Guo L., Tong W., Ning B.
Arch Toxicol. 2020, 94(5):1637-1653. doi: 10.1007/s00204-020-02706-5. Epub 2020 Mar 28.

Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells.
Yu D., Chen J., Chen S., Xu L., Wu L., Li D., Luo J., Jin Y., Zhao Y., Knox B., Tolleson W.H., Wang X., Guo L., Tong W., and Ning B.
Drug Metab Dispos. 2020, 48(4):297-306. doi: 10.1124/dmd.119.090043. Epub 2020 Feb 21.

Using a Lentivirus-Based Inducible RNAi Vector to Silence a Gene.
Chen S., Li D., Ren Z., Yu D., Ning B., Mei N., and Guo L.
Methods Mol Biol. 2020, 2102:195-210. doi: 10.1007/978-1-0716-0223-2_10.

FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA.
Yu D., Chen S., Li D., Knox B., Guo L., and Ning B.
Methods Mol Biol. 2020, 2102:557-566. doi: 10.1007/978-1-0716-0223-2_30.

MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p Suppress Basal and Rifampicin-Induced Expression of Human Sulfotransferase 2A1 (SULT2A1) by Facilitating mRNA Degradation.
Li D., Knox B., Chen S., Wu L., Tolleson W.H., Liu Z., Yu D., Guo L., Tong W., and Ning B.
Biochem Pharmacol. 2019, 169:113617. doi: 10.1016/j.bcp.2019.08.019. Epub 2019 Aug 22.

Regulation of Cytochrome P450 Expression by microRNAs and Long Noncoding RNAs: Epigenetic Mechanisms in Environmental Toxicology and Carcinogenesis.
Li D., Tolleson W.H., Yu D., Chen S., Guo L., Xiao W., Tong W., and Ning B.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2019, 37(3):180-214. doi: 10.1080/10590501.2019.1639481. Epub 2019 Jul 15.

Membrane-Associated Androgen Receptor (AR) Potentiates its Transcriptional Activities by Activating Heat Shock Protein 27 (HSP27).
Li J., Fu X., Cao S., Li J., Xing S., Li D., Dong Y., Cardin D., Park H.W., Mauvais-Jarvis F., and Zhang H.
J Biol Chem. 2018, 293(33):12719-12729. doi: 10.1074/jbc.RA118.003075. Epub 2018 Jun 22.

Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance.
Zhan Y., Zhang G., Wang X., Qi Y., Bai S., Li D., Ma T., Sartor O., Flemington E.K., Zhang H., Lee P., and Dong Y.
Mol Cancer Res. 2017, 15(1):59-68. doi: 10.1158/1541-7786.MCR-16-0236. Epub 2016 Sep 26.

A Whole Blood Assay for AR-V7 and ARv567es in Patients with Prostate Cancer.
Liu X., Ledet E., Li D., Dotiwala A., Steinberger A., Feibus A., Li J., Qi Y., Silberstein J., Lee B., Dong Y., Sartor O., and Zhang H.
J Urol. 2016, 196(6):1758-1763. doi: 10.1016/j.juro.2016.06.095. Epub 2016 Jul 20.

Cingulin and Actin Mediate Midbody-Dependent Apical Lumen Formation During Polarization of Epithelial Cells.
Mangan A.J., Sietsema D.V., Li D., Moore J.K., Citi S., and Prekeris R.
Nat Commun. 2016, 7:12426. doi: 10.1038/ncomms12426.

Identification of Rare DNA Sequence Variants in High-Risk Autism Families and their Prevalence in a Large Case/Control Population.
Matsunami N., Hensel C.H., Baird L., Stevens J., Otterud B., Leppert T., Varvil T., Hadley D., Glessner J.T., Pellegrino R., Kim C., Thomas K., Wang F., Otieno F.G., Ho K., Christensen G.B., Li D., Prekeris R., Lambert C.G., Hakonarson H., and Leppert M.F.
Mol Autism. 2014, 5(1):5. doi: 10.1186/2040-2392-5-5.

Kinesin-2 Mediates Apical Endosome Transport During Epithelial Lumen Formation.
Li D., Kuehn E.W., and Prekeris R.
Cell Logist. 2014, 4(1):e28928. doi: 10.4161/cl.28928. Epub 2014 May 6.

FIP5 Phosphorylation During Mitosis Regulates Apical Trafficking and Lumenogenesis.
Li D., Mangan A., Cicchini L., Margolis B., and Prekeris R.
EMBO Rep. 2014, 15(4):428-37. doi: 10.1002/embr.201338128. Epub 2014 Mar 3.