Veterinary Laboratory Investigation and Response Network (Vet-LIRN)

Biography

Andriy Tkachenko received his bachelor’s degree in 1997 from the National Agricultural University, Ukraine, where he examined the behavior of radioactive strontium and cesium in the plant-soil system. In 2002, he received his master’s degree from the University of Manchester, United Kingdom jointly with the Central European University, Hungary, where he investigated the behavior and toxicity of metals in aquatic animals. In 2010, he earned his PhD from the University of Maryland Eastern Shore, where he characterized the susceptibility of aquatic animals to environmental stressors and diseases using chemical and biochemical approaches in combination with analytical equipment.

Dr. Tkachenko joined FDA in 2010 as an Oak Ridge Associated Universities (ORAU) fellow, working primarily on setting up analytical instrumentation for the newly established Veterinary Laboratory Investigation and Response Network (Vet-LIRN). Dr. Tkachenko performs chemical analysis of research and investigational samples. In 2016, Dr. Tkachenko became a physical scientist for Vet-LIRN.

Research

As a physical scientist, Dr. Tkachenko (i) coordinates communications between Vet-LIRN Collaborative Agreement Program (CAP) funded laboratories and the Vet-LIRN program office; (ii) provides technical assistance, advice, and guidance in development and validation of chemistry and microbiology methods by CAP laboratories according to FDA Guidelines, International Organization for Standardization (ISO) and Association of Official Analytical Chemists (AOAC) documents; (iii) reviews results and reports on progress of CAP laboratory method validation projects; (iv) designs, organizes, conducts, and evaluates method testing exercises called Blinded Method Tests (BMTs) for individual CAP laboratory projects, and (v) assists in designing, organizing, and conducting activities including evaluation of results under the Proficiency Test program for Vet-LIRN Network Laboratories in collaboration with the Moffett Campus, FDA.

Select Publications

K. Deng, S. Uhlig, L. Goodman, H. Ip, M. Killian, S. Nemser, J. Ulaszek, S. Kiener, M. Kmet, K. Frost, K. Hettwer, B. Colson, K. Nichani, A. Schlierf, A. Tkachenko, M. Mlalazi-Oyinloye, A. Scott, R. Reddy, G. Tyson. Second round of the interlaboratory comparison (ILC) exercise of SARS-CoV-2 molecular detection assays being used by 45 veterinary diagnostic laboratories in the US. Journal of Veterinary Diagnostic Investigation. 2022.

S. Nemser, S. Lindemann, Y. Chen, S. Lopez, S. Pickens, J. Ulaszek, M. Kmet, C. Powers, S. Ensley, D. Schrunk, W. Rumbeiha, A. Tkachenko, J. Guag, O. Ceric, J. Jones, R. Reimschuessel, R. Reddy. A Review of Proficiency Exercises Offered by the Veterinary Laboratory Investigation and Response Network and Moffett Proficiency Testing Laboratory from 2012 to 2018. Accreditation and Quality Assurance. 2021. 

Andriy Tkachenko, K. Benson, M. Mostrom, J. Guag, R. Reimschuessel and B. Webb. Extensive evaluation via blinded testing of an UHPLC-MS/MS method for quantitation of ten ergot alkaloids in rye and wheat grains. Journal of AOAC International. 2021. 

Du X, Schrunk DE, Imerman P, Smith L, Francis K, Tahara J, Tkachenko A, Reimschuessel R, and Rumbeiha W. Evaluation of a diagnostic method to quantify aflatoxins B1 and M1 in animal liver by high-performance liquid chromatography with fluorescence detection. Journal of AOAC International. 2019.

Lori L. Smith, Boying Liang, Marcia C. Booth, Michael S. Filigenzi, Andriy Tkachenko and Cynthia L. Gaskill. Development and Validation of Quantitative UPLC-MS/MS Assay for Anticoagulant Rodenticides in Liver. Journal of Agricultural Food and Chemistry. 2017.