Drugs with Veterinary Feed Directive (VFD) Marketing Status
This list represents the medically important antimicrobials approved for use in or on animal feed that require a VFD, including those that transitioned from over-the-counter (OTC) to VFD marketing status upon completion of the implementation of Guidance for Industry (GFI) #213.
Please note that as a result of the implementation of GFI #213, approvals for penicillin alone or penicillin in fixed combination with chlortetracycline/sulfamethazine for use in animal feed have been voluntarily withdrawn. Additionally, the approval for oleandomycin was voluntarily withdrawn in 2017.
All feed uses of the following drugs, alone and in a combination with another drug(s), require a VFD:
Drugs that require a VFD
| Established drug name |
|---|
| apramycin |
| avilamycin1 |
| chlortetracycline (CTC) |
| chlortetracycline/sulfamethazine2 |
| erythromycin |
| florfenicol1 |
| hygromycin B |
| lincomycin |
| oxytetracycline/neomycin2 |
| sulfadimethoxine/ormetoprim2 |
| sulfamerazine |
| sulfaquinoxaline |
| tilmicosin1 |
| tylosin |
| tylosin/sulfamethazine2 |
| tylvalosin1 |
| virginiamycin |
1Drug product that has been VFD since its approval, and continues to require a VFD
2Fixed-ratio, combination drug
Note: Some of the VFD drugs on the list above may not be marketed at this time. If you have questions regarding the availability of a VFD drug, contact your local distributor.
Additional Resources
- Veterinary Feed Directive (VFD)
- Blue Bird Labels
- Animal Drugs @ FDA
- Judicious Use of Antimicrobials
- List of all applications affected by the GFI #213/209 OTC to VFD (or Rx) transition