Division of Residue Chemistry

Biography

Dr. Li is a chemist with the Division of Residue Chemistry in the Office of Research at FDA’s Center for Veterinary Medicine (CVM). He received his PhD in bio-organic chemistry from Duke University in 2001, and joined FDA/CVM in 2002. Dr. Li conducts method development and applied research for regulatory purposes, focusing on veterinary drug residues in animal products and toxic chemicals in feeds.

Research

• Regulatory method development and validation
• Drug depletion analysis and tissue-fluid correlation
• Rapid test kits evaluation

Select Publications

Michael J. Myers, Marilyn Martinez, Hui Li, Junshan Qiu, Lisa Troutman, Michele Sharkey, and Haile F. Yancy. Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study. Drug Metabolism and Disposition. 2015, 43: 1392-1407

Hui Li. Confirmatory Methods for Veterinary Drugs and Chemical Contaminants in Livestock Commodities. in Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management, and Testing. (eds. Ronald E. Baynes and Jim Riviere), John Wiley & Sons, Inc, Hoboken, New Jersey. doi: 10.1002/9781118872819.ch13

Shixia Feng, Oscar A. Chiesa, Philip Kijak, Chaitali Chattopadhaya, Vicki Lancaster, Elizabeth A. Smith, Lauren Girard, Sara Sklenka, and Hui Li. Determination of Ceftiofur Metabolite Desfuroylceftiofur Cysteine Disulfide in Bovine Tissues Using Liquid Chromatography-Tandem Mass Spectrometry as a Surrogate Marker Residue for Ceftiofur. Journal of Agriculture and Food Chemistry. 2014, 691 (62): 5011–5019

O. A. Chiesa, H. Li, P. J. Kijak, J. X. Li, V. Lancaster, M. L. Smith, D. N. Heller, M. H. Thomas, J. Von Bredow. Tissue-Fluid Correlation Study for the Depletion of Sulfadimethoxine in Bovine Kidney, Liver, Plasma, Urine, and Oral Fluid. Journal of Veterinary Pharmacology and Therapeutics. 2011, 35: 249–258

Hui Li, Philip J. Kijak. Development of a Quantitative Multi Class/Multi Residue Method for 21 Veterinary Drugs in Shrimp. Journal of AOAC International. 2011, 94(2): 394–406

Hui Li, Michelle L. Smith, O. Alberto Chiesa, Philip J. Kijak. Determination of Sulfadimethoxine and ⁴N-Acetylsulfadimethoxine in Bovine Plasma, Urine, Oral Fluid, and Kidney and Liver Biopsy Samples Obtained Surgically From Standing Animals by LC/MS/MS. Journal of Chromatography B. 2009, 877: 237–246