Division of Applied Veterinary Research

Biography

Michael Myers obtained his doctorate from Indiana University in 1984, where he majored in pharmacology with a minor in immunology. He was a post-doctoral fellow in the Department of Microbiology & Immunology, Medical College of Virginia from 1984 to 1986, and then completed a two-year post-doctoral fellowship in the Laboratory of Molecular Immunology in the Department of Animal Sciences, University of Illinois. He was a senior staff fellow in the Laboratory of Molecular Carcinogenesis, in the National Cancer Institute, NIH, from 1988 to 1990. He joined the US FDA Center for Veterinary Medicine in 1990 as a research pharmacologist.

Research

Dr. Myers’ research activities focus on the identification and qualification of biomarkers of inflammation in food-producing animals that can serve as surrogate endpoints to substantiate drug claims to control inflammation. An integral part of these efforts is the validation of the systems necessary to demonstrate the in vivo utility of these biomarkers. The goal of these efforts is to generate validated models and qualified surrogate endpoints of inflammation that can be transferred for use by individuals or companies seeking to develop therapeutics to control inflammation in food-producing animals.

Other research activities center on drug pharmacokinetics and pharmacodynamics in food-producing and companion animals. He also collaborates on the identification and characterization of veterinary-derived mesenchymal stem cells.

Select Publications

Olumee-Shabon, Z., Chattopadhaya, C., and Myers, MJ.  2020.  Proteomics profiling of swine serum following lipopolysaccharide stimulation. Rapid Communications in Mass Spectrometry. 37(4): e8639.  DOI: 10.1002/rcm.8639

Myers MJ, Deaver CM, Lewandowsk, A. 2019.  Molecular mechanism of action responsible for carrageenan-induced inflammatory response.  Molecular Immunology 109:38-42.

Myers MJ, Deaver CM. 2019. Identification of Protein Biomarkers of Inflammation-Induced Pain. Research in Veterinary Science 122:186-188.

Devireddy LR, Myers MJ. Screven R, Boxer L. 2019. A serum-free medium formulation efficiently supports isolation and propagation of canine adipose-derived mesenchymal stem/stromal cells. PLoS ONE 14(2): e0210250.  

Myers MJ, Martinez M, Li F, Howard KD, Yancy HF, Troutman L, Sharkey M. 2018.  Impact of ABCB1 Genotype in Collies on the Pharmacokinetics of Fexofenadine and Its R- and S-Enantiomers. J Veterinary Pharmacology & Therapeutics. 41(5):805-814.  

Devireddy LR, Myers MJ, Screven R, Boxer L, Liu Z. 2018 Characterization of canine adipose-derived mesenchymal stromal/stem cells in serum-free medium.  Tissue Engineering Part C Methods Jul;24(7):399-411.

Li F, Howard KD, Myers MJ.  2017.  Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers. J. Pharmacy and Pharmacology. 69(3):274-284. 

Devireddy L, Boxer L, Myers MJ, Skasko M, Screven R. 2017.  Questions and challenges in the development of mesenchymal stromal/stem cell-based therapies in veterinary medicine. Tissue Engineering, Part B. Oct;23(5):462-470. 

Myers MJ, Turfle PG, Smith ER. 2017. Biomarkers in Veterinary Medicine. Annual Reviews in Animal Biosciences. Vol 5:65–87.

Chiesa OA, Heller DN, Karanian JW, Pritchard WF, Smith S, Kijak PJ, Ward JL, Bredow J, Myers MJ. Inhalation anesthesia induced by isoflurane alters penicillin disposition in swine tissues. Journal of Veterinary Pharmacology and Therapeutics. 2016 Sep 1.

Kawalek JC, Howard KD, Jones Y, Scott ML, Myers MJ. Depletion of florfenicol in lactating dairy cows after intramammary and subcutaneous administration. Journal of Veterinary Pharmacology and Therapeutics. 2016 Dec 1;39(6):602–11.

Zhu M, Yancy HF, Deaver C, Jones YL, Myers MJ. Loperamide‐induced expression of immune and inflammatory genes in collies associated with ivermectin sensitivity. Journal of Veterinary Pharmacology and Therapeutics. 2016 Apr 1;39(2):131–7.

Myers MJ, Martinez M, Li H, Qiu J, Troutman L, Sharkey M, Yancy HF. Influence of ABCB1 genotype in collies on the pharmacokinetics and pharmacodynamics of loperamide in a dose-escalation study. Drug Metabolism and Disposition: The Biological Fate of Chemicals. 2015 Sep;43(9):1392–407.

Zhu M, Ming Y, Swaim H, Swain MD, Myers MJ, Deaver C, Wu X, Jones YL, Yancy HF. Identification of potential biomarkers of P-glycoprotein substrate neurotoxicity in transgenic mice expressing the mutated canine ABCB1 gene. American Journal of Veterinary Research. 2014 Dec;75(12):1104–10.

Screven R, Kenyon E, Myers MJ, Yancy HF, Skasko M, Boxer L, Bigley EC, Borjesson DL, Zhu M. Immunophenotype and gene expression profile of mesenchymal stem cells derived from canine adipose tissue and bone marrow. Veterinary Immunology and Immunopathology. 2014 Sep 15;161(1):21–31.

Martinez MN, Antonovic L, Court M, Dacasto M, Fink-Gremmels J, Kukanich B, Locuson C, Mealey K, Myers MJ, Trepanier L. Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics. Drug Metabolism Reviews. 2013 May 1;45(2):218–30.

Swain MD, Orzechowski KL, Swaim HL, Jones YL, Robl MG, Tinaza CA, Myers MJ, Jhingory MV, Buckely LE, Lancaster VA, Yancy HF. P-gp substrate-induced neurotoxicity in an Abcb1a knock-in/Abcb1b knock-out mouse model with a mutated canine ABCB1 targeted insertion. Research in Veterinary Science. 2013 Jun 30;94(3):656–61.

Peters SM, Yancy HF, Deaver CM, Jones YL, Kenyon E, Chiesa OA, Esparza J, Screven R, Stubbs III JT, Lancaster V, Yang M, Wiesenfeld PL, Myers MJ. In vivo characterization of inflammatory biomarkers in swine and the impact of flunixin meglumine administration. Veterinary Immunology and Immunopathology. 2012 Aug 15; 148(3):236–242.

Kenyon EA, Peters SM, Jones YL, Deaver CM, Myers MJ, Yancy H. In vitro characterization of inflammatory biomarkers across species. Journal of Advanced Veterinary Research. 2012 Apr 1;2(2):80–5.

Ekins J, Peters SM, Jones YL, Swaim H, Ha T, La Neve F, Civera T, Blackstone G, Vickery MC, Marion B, Myers MJ. Development of a multiplex real-time PCR assay for the detection of ruminant DNA. Journal of Food Protection. 2012 Jun;75(6):1107–12.

Orzechowski KL, Swain MD, Robl MG, Tinaza CA, Swaim HL, Jones YL, Myers MJ, Yancy HF. Neurotoxic effects of ivermectin administration in genetically engineered mice with targeted insertion of the mutated canine ABCB1 gene. American Journal of Veterinary Research. 2012 Sep;73(9):1477–84.

Peters SM, Yancy H, Bremer E, Monroe J, Paul D, Stubbs JT, Myers MJ. In vitro identification and verification of inflammatory biomarkers in swine. Veterinary Immunology and Immunopathology. 2011 Jan 31;139(1):67–72.

Myers MJ. Molecular identification of animal species in food: Transition from research laboratories to the regulatory laboratories. The Veterinary Journal. 2011;1(190):7–8.