Spotlight on CDER Science
Summaries of research conducted by CDER staff
Bispecific Antibodies: An Area of Research and Clinical Applications
Bispecific antibodies (BsAbs) have two distinct binding domains that can bind to two antigens or two epitopes (an antigen part) of the same antigen simultaneously. Over the past two decades, BsAb development has been revolutionized due to genetic engineering approaches that enable a wide variety of molecular structures that offer different advantages and disadvantages.