Senior Staff Fellow — Division of Systems Biology

Tao Han, Ph.D.
(870) 543-7121
NCTRResearch@fda.hhs.gov  

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About  |  Publications  |  Lab Members

Background

Dr. Tao Han received a B.S. degree in microbiology and an M.S. degree in microbiology from Shandong University, P.R. China. He received a Ph.D. in microbiology from the Institute of Plant Physiology, Chinese Academy of Science. Dr. Han worked as a postdoctoral fellow at Ohio State University and then as a research scientist at the University of Florida before joining FDA’s National Center for Toxicological Research (NCTR) in 2004. Currently he is a staff fellow in the Division of Systems Biology at NCTR.

Research Interests

Over the years, Dr. Han’s research has focused primarily on drug-related hepatotoxicity and cardiotoxicity. One of his research interests is to identify early biomarkers by using omics technologies. He has published 38 research papers (author and co-author) related to mechanisms of hepatoxicity and cardiotoxicity. In a recently approved NCTR protocol, “Systems biology approach to identify early biomarkers of sunitinib‐induced cardiac toxicity in a mouse model,” he plans to use omics technologies to study the mechanism of cardiotoxicity induced by sunitinib (a tyrosine kinase inhibitor) in a mouse model.

Professional Societies/National and International Groups

American Society for Microbiology
Member
2000 – Present

Select Publications

Doxorubicin-Induced Delayed-Onset Subclinical Cardiotoxicity in Mice.
Desai V.G., Vijay V., Han T., Moland C.L., Phanvanh B., Lee T., Davis K.J., Muskhelishvili L., Stine K.C., and Fuscoe J.C.
J Appl Toxicol. 2021, doi:10.1002/jat.4256. 

Hepatic Transcript Profiles of Drug Metabolizing Genes Predict Sex Differences in Drug Metabolism.
Fuscoe J.C., Vijay V., Hanig J.P., Han T., Ren L., Greenhaw J.J., Beger R.D., Pence L.M., and Shi Q.
Drug Metab Dispos. 2020, pii: dmd.119.089367. 

Candidate Early Predictive Plasma Protein Markers of Doxorubicin-Induced Chronic Cardiotoxicity in B6C3F1 Mice. 
Desai V., Lee T., Moland C., Vijay V., Han T., Lewis S., Herman E., and Fuscoe J.C. 
Toxicol Appl Pharmacol. 2019, 363:164-173.

Transcript Profiling in the Testes and Prostates of Postnatal Day 30 Sprague-Dawley Rats Exposed Prenatally and Lactationally to 2-hydroxy-4-methoxybenzophenone.
Nakamura N., Vijay V., Desai V.G., Hansen D.K., Han T., Change C.-W., Chen Y.C., Harrouk W., McIntyre B., Foster P.M., Fuscoe J.C., and Inselman A.L.
Reprod Toxicol. 2018, 82: p. 111-123.

Sex and Age Differences in the Expression of Liver microRNAs During the Life Span of F344 Rats.
Kwekel J.C., Vijay V., Han T., Moland C.L., Desai V.G., and Fuscoe J.C.
Biol Sex Differ. 2017, 8: p. 6.

Transcriptomics Analysis of Early Embryonic Stem Cell Differentiation Under Osteoblast Culture Conditions: Applications for Detection of Developmental Toxicity.
Chen X., Han T., Fisher J.E., Harrouk W., Tassinari M.S., Merry G.E., Sloper D., Fuscoe J.C., Hansen D.K., and Inselman A.L.
Reprod Toxicol. 2017, 69: p. 75-83.

Early Transcriptional Changes in Cardiac Mitochondria During Chronic Doxorubicin Exposure and Mitigation by Dexrazoxane in Mice.
Vijay V., Moland C.L, Han T., Fuscoe J.C., Lee T., Herman E.H., Jenkins G.R., Lewis S.M., Cummings C.A., Gao Y., Cao Z., Yu L.-R., and Desai V.G.
Toxicol Appl Pharmacol. 2016, 295: p. 68-84.

Status of Hepatic DNA Methylome Predetermines and Modulates the Severity of Non-Alcoholic Fatty Liver Injury in Mice.
Tryndyak V.P., Han T., Fuscoe J.C., Ross S.A., Beland F.A., and Pogribny I.P.
BMC Genomics. 2016, 17: p. 298.

Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages.
Vijay V., Han T., Moland C.L., Kwekel J.C., Fuscoe J.C., and Desai V.G.
PloS One. 2015, 10(1):e0117047.

Persistence of Furan-Induced Epigenetic Aberrations in the Livers of F344 Rats.
de Conti A., Kobets T., Tryndyak V., Burnett S.D., Han T., Fuscoe J.C., Beland F.A., Doerge D.R., and Pogribny I.P.
Toxicological Sciences. 2015, 144(2):217-226.

Effects of Oral Exposure to Bisphenol A on Gene Expression and Global Genomic DNA Methylation in the Prostate, Female Mammary Gland, and Uterus of NCTR Sprague-Dawley Rats.
Camacho L., Basavarajappa M.S., Chang C.W., Han T., Kobets T., Koturbash I., Surratt G., Lewis S.M., Vanlandingham M.M., Fuscoe J.C., Gamboa da Costa G., Pogribny I.P., and Delclos K.B.
Food and Chemical Toxicology. 2015, 81:92-103.

MicroRNA-155 Deficient Mice Experience Heightened Kidney Toxicity when Dosed with Cisplatin.
Pellegrini K.L., Han T., Bijol V., Saikumar J., Craciun F.L., Chen W.W., Fuscoe J.C., and Vaidya V.S.
Toxicological Sciences. 2014, 141(2):484-492.

Transcriptomic Responses Provide a New Mechanistic Basis for the Chemopreventive Effects of Folic Acid and Tributyrin in Rat Liver Carcinogenesis.
Guariento A.H., Furtado K.S., de Conti A., Campos A., Purgatto E., Carrilho J., Shinohara E.M., Tryndyak V., Han T., Fuscoe J.C., Ross S.A., Beland F.A., Pogribny I.P., and Moreno F.S.
International Journal of Cancer. 2014, 135(1):7-18.

Differential Gene Expression in Human Hepatocyte Cell Lines Exposed to the Antiretroviral Agent Zidovudine.
Fang J.L., Han T., Wu Q., Beland F.A., Chang C.W., Guo L., Fuscoe J.C.
Archives of Toxicology. 2014, 88(3):609-623.

Early Biomarkers of Doxorubicin-Induced Heart Injury in a Mouse Model.
Desai V.G., Kwekel J.C. , Vijay V., Moland C.L., Herman E.H., Lee T., Han T., Lewis S.M., Davis K.J., Muskhelishvili L., Kerr S., and Fuscoe J.C.
Toxicology and Applied Pharmacology. 2014, 281(2):221-229.

The Liver Toxicity Biomarker Study Phase I: Markers for the Effects of Tolcapone or Entacapone.
McBurney R.N., Hines W.M., VonTungeln L.S., Schnackenberg L.K., Beger R.D., Moland C.L., Han T., Fuscoe J.C., Chang C.W., Chen J.J., Su Z., Fan X.H., Tong W., Booth S.A., Balasubramanian R., Courchesne P.L., Campbell J.M., Graber A., Guo Y., Juhasz P., Li T.Y., Lynch M.D., Morel N.M., Plasterer T.N., Takach E.J., Zeng C., and Beland F.A. 
Toxicologic Pathology. 2012, 40(6):951-964.

Technical Reproducibility of Genotyping SNP Arrays Used in Genome-Wide Association Studies.
Hong H., Xu L., Liu J., Jones W.D., Su Z., Ning B., Perkins R., Ge W., Miclaus K., Zhang L., Park K., Green B., Han T., Fang H., Lambert C.G., Vega S.C., Lin S.M., Jafari N., Czika W., Wolfinger R.D., Goodsaid F., Tong W., and Shi L.
PloS One. 2012, 7(9):e44483.

Characterization of Whole Genome Amplified (WGA) DNA for Use in Genotyping Assay Development.
Han T., Chang C.W., Kwekel J.C., Chen Y., Ge Y., Martinez-Murillo F., Roscoe D., Tezak Z., Philip R., Bijwaard K., and Fuscoe J.C.
BMC Genomics. 2012, 13:217.

Coupling Global Methylation and Gene Expression Profiles Reveal Key Pathophysiological Events in Liver Injury Induced by a Methyl-Deficient Diet.
Tryndyak V.P., Han T., Muskhelishvili L., Fuscoe J.C., Ross S.A., Beland F.A., and Pogribny I.P.
Molecular Nutrition & Food Research. 2011, 55(3):411-418.

Lab Members

Contact Information for all lab members:
(870) 543-7121
NCTRResearch@fda.hhs.gov

Carrie L. Moland
Biologist

Bounleut Phanavanh
Biologist