Imipenem-cilastatin-relebactam Injection

FDA Identified Breakpoints

	Minimum Inhibitory Concentrations (mcg/mL)			Disk Diffusion ^a (zone diameter in mm)
Pathogen	S	I	R	S	I	R
Enterobacteriaceae ^b	M-100 standard is recognized
*Pseudomonas aeruginosa*	M-100 standard is recognized
*Acinetobacter calcoaceticus-baumannii complex*	≤2/4	4/4	≥8/4	-	-	-
*Haemophilus influenzae*	≤4/4	-	-	-	-	-
Anaerobes ^c,d	M-100 standard is recognized			-	-	-

S = Susceptible; I = Intermediate; R = Resistant

^a For disk diffusion, use paper disks impregnated with imipenem/relebactam at a concentration of 10/25 mcg/mL.
^b Clinical efficacy was shown for Klebsiella aerogenes, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Klebsiella oxytoca.
^c Clinical efficacy was shown for Bacteroides caccae, Bacteroides fragilis, Bacteroides ovatus, Bacteroides stercoris, Bacteroides thetaiotaomicron, Fusobacterium nucleatum, Parabacteroides distasonis.
^d Agar dilution method.