Mechanical Engineer — Division of Biochemical Toxicology

Jinghai Yi, Ph.D.
(870) 543-7121
NCTRResearch@fda.hhs.gov  

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About  |  Publications | Lab Members

Background

Dr. Jinghai Yi received his bachelor’s degree, master’s degree and Ph.D. in energy and power engineering from Xi’an Jiaotong University in Xi’an, China. After graduation, he worked for the Power Machinery Engineering Department of Shanghai Jiaotong University in Shanghai, China, as a lecturer and a postdoctoral fellow.  He continued his research in mechanical engineering school at Technion-Israel Institute of Technology and Purdue University, and in petroleum engineering department at Louisiana State University. In 2001, he was hired as a mechanical engineer at Doty Scientific before joining BioTechPlex as a senior mechanical engineer. In 2007, Dr. Yi was hired as a senior inhalation engineer for Technical Research Institute at Philip Morris. Most recently, Dr. Yi was a research assistant professor and inhalation engineer at West Virginia University before he joined FDA/NCTR as a mechanical engineer in 2017.

Dr. Yi received a National Institutes of Health (NIH) Small Business Innovation Research (SBIR) grant and an NIH National Institute for Occupational Safety and Health (NIOSH) subcontract, and was awarded the Lila Albin Paper Award for 2017 (co-author). He has also been awarded two U.S. patents and one Chinese patent.

Research Interests

Dr. Yi’s research interests include 1) inhalation toxicology, 2) aerosol generation and characterization, and 3) design, fabrication, setup, validation, and operation of whole-body and nose-only inhalation exposure systems. He conducts inhalation studies in collaboration with FDA’s Center for Tobacco Products (CTP) to characterize and quantify the health risk associated with selected chemicals found in tobacco products.

Dr. Yi’s awards and research projects are listed below.

• Lila Albin Paper Award for 2017 (co-author)
• Principle Investigator (PI), Support and Infrastructure for CTP/NCTR Inhalation Facility, FDA Center for Tobacco Products (CTP), 09/2017- 09/30/2020
• PI, Pharmacokinetic Analysis of Nicotine in Sprague-Dawley Rats,  FDA Center for Tobacco Products, 11/2017-ongoing
• Consultant of a NIH SBIR grant, Aerosol Delivery of Surfactant for ARDS, 1R43HL127834-01, 09/2015-05/2016 (PI: Yeates)
• PI of a NIOSH contract, Inhalation Facility of Desktop 3D Printer Emissions, Contract No. 212-2015-M-63382, 08/2015-08/2016
• Co-investigator of a NIOSH contract, Cardiovascular Effect of Desktop 3D Printer Emissions, 08/2015-08/2016
• PI of a NIH SBIR grant, Ultra-High Dose Rate Aerosol Drug Delivery, R43HL078281-01, 12/2004-12/2005
• Co-investigator of a NIH SBIR grant, Concentrated Aerosol Delivery and Quantization System 09/2001-07/2004. (PI: Yeates).
• Co-investigator of a NIH SBIR grant, Water and Ion Measurement System, 5R44HL067008, (PI: Wong)
• Co-investigator of a NIH SBIR grant, 2R44RR015150-02A1 (PI: Mao)

Professional Societies/National and International Groups

Society of Toxicology
Member
2009 – 2014

Selected Publications 

Estrous Cycle-Dependent Modulation of In Vivo Microvascular Dysfunction After Nanomaterial Inhalation.
Stapleton P., McBride C., Yi J., Abukabda A., and Nurkiewicz T.
Reproductive Toxicology 78. 2018, DOI: 10.1016/j.reprotox.2018.03.001.

Maternal Engineered Nanomaterial Inhalation During Gestation Alters the Fetal Transcriptome.
Stapleton P., Hathaway Q., Nichols C., Abukabda A., Pinti M., Shepherd D., McBride C., Yi J., Castranova V., Nurkiewicz T., and Hollander J.
Particle and Fibre Toxicology. 2018, 15:3 DOI 10.1186/s12989-017-0239-8.

Reactive Oxygen Species Damage Drives Cardiac and Mitochondrial Dysfunction Following Acute Nano-Titanium Dioxide Inhalation Exposure.
Nichols C., Shepherd D., Thapa D., Yi J., Dabkowski E., Nurkiewicz T., and Hollander J.
Nanotoxicology. 2017.

Developing a Link Between Cardiac Function and Maternal Engineered Nanomaterial Exposure in Growing Progeny.
Hathaway Q., Nichols C., Shepherd D., Stapleton P., McLaughlin S., Stricker J., Rellick S., Pinti M., Abukabda A., McBride C.,  Yi J., Stine S., Nurkiewicz T., and Hollander J. 
The FASEB Journal. 2017, vol. 31  no. 1 Supplement  843.3.

Heterogeneous Vascular Bed Responses to Pulmonary Titanium Dioxide Nanoparticle Exposure.
Abukabda A., Stapleton P., McBride C., Yi J., and Nurkiewicz T. 
Front Cardiovasc Med. 2017, 4: 33.  https://doi.org/10.3389/fcvm.2017.00033.

Characterization of Chemical Contaminants Generated by a Desktop Fused Deposition Modeling 3-Dimensional Printer.
Stefaniak A., LeBouf R., Yi J.,Duling M., Nurkewicz T., Schwegler-Berry D., Chen B., and Virji A.
Journal of Occupational and Environmental Hygiene. 2017, 25:0. doi: 10.1080/15459624.2017.1302589.

Maternal Engineered Nanomaterial Exposure Disrupts Progeny Cardiac Function and Bioenergetics.
Hathaway Q., Nichols C., Shepherd D., Stapleton P., McLaughlin S., Stricker J., Rellick S., Pinti M., Abukabda A., McBride C., Yi J., Stine S., Nurkiewicz T., and Hollander J.
American Journal of Physiology - Heart and Circulatory Physiology. 2017, DOI: 10.1152/ajpheart.00634.2016.

Emission of Particulate Matter From a Desktop Three-Dimensional (3D) Printer.
Yi J., LeBouf R., Duling M., Nurkiewicz T., Chen B., Schwegler-Berry D., Virji M., and Stefaniak, A.
Journal of Toxicology and Environmental Health. 2016, Part A. DOI: 10.1080/15287394.2016.1166467.

Adult Behavioral Consequences of Prenatal Engineered Nanomaterial Exposure in Rodents.
Engler-Chiurazzi E., Stapleton P., Stalnaker J., Rambo-Hernandez K., Sarkar S., Jun S., Quintana D., Ren X., Hu H., Nurkiewicz T., McBride C., Yi J., and Simpkins J.
Journal of Toxicology and Environmental Health. 2016, 19:1-6.

Comparative Plasma Proteomic Studies of Pulmonary TiO2 Nanoparticle Exposure in Rats Using Liquid Chromatography Tandem Mass Spectrometry.
Maurer M., Donohoe G., Maleki H., Yi J., McBride C., Nurkiewicz T., and Valentine S.
J Proteomics. 2016, 130:85-93.

Uterine Microvascular Sensitivity to Nanomaterial Inhalation: an In Vivo Assessment.
Stapleton P., McBride C., Yi J., and Nurkiewicz, T.
Toxicol Appl Pharmacol. 2015, 288(3):420-8. doi: 10.1016/j.taap.2015.08.013.

Microvascular and Mitochondrial Dysfunction in the Female F1 Generation After Gestational TiO2 Nanoparticle Exposure.
Stapleton P., Nichols C., Yi J., McBride C., Minarchick V., Shepherd D., Hollander J., and Nurkiewicz T.
Nanotoxicology. 2015, Volume 9, Issue 8, pages 941-951.

A New Ion Mobility – Linear Ion Trap Instrument for Complex Mixture Analysis.
Donohoe G., Maleki H., Arndt J., Khakinejad M., Yi J., McBride C., Nurkiewicz T., and Valentine S.
Analytical Chemistry. 2014.

Whole-Body Nanoparticle Aerosol Inhalation Exposures.
Yi J., Chen B., Schwegler-Berry D., Frazer D., Castranova V., McBride C., Knuckles T., Stapleton P., Minarchick V., and Nurkiewicz T.
J. Vis. Exp. 2013, (75), e50263. doi:10.3791/50263.

Does the Barker Hypothesis Apply to Maternal Engineered Nanomaterial Exposure and Fetal Microvascular Function?
Stapleton P., Minarchick V., Yi J., Engels K., McBride C., and Nurkiewicz T.
American Journal of Obstetrics and Gynecology. 2013, PMID: 23643573.

Nanoparticle Inhalation Alters Arteriolar Vasoreactivity through Sympathetic and Cyclooxygenase-Mediated Pathways.
Knuckles T., Yi J., Frazer D., Leonard H., Chen B., Castranova V., and Nurkiewicz T.
Nanotoxicology. 2012, 6(7): 724-735. PMID: 21830860.

Dispersion of a Particle-laden Air Jet in a Confined Rectangular Crossflow.
Yi J. and Plesniak M.
Powder Technology. 2002, Vol. 125, pp. 168-178.

Lab Members

Contact information for all lab members:
(870) 543-7121
NCTRResearch@fda.hhs.gov

Seonggi Min, Ph.D.
Staff fellow

Gregory Pellar, Ph.D.
Staff fellow

Yunan Tang, Ph.D., DABT
Staff fellow

Qiangen Wu, Ph.D., DABT
Staff fellow

Dong-Jin Yang, MS
Staff fellow