Fluconazole

Exceptions to the Recognized Standard

	Minimum Inhibitory Concentrations (mcg/mL) Broth Microdilution at 24 Hours			Disk Diffusion (zone diameters in mm) Disk Diffusion at 24 Hours
Pathogen^a	S	I^c	R	S	I^c	R
Candida albicans	M60^b	4	M60^b	M60^b	14-16	M60^b
Candida glabrata	M60^b	< 32	M60^b	M60^b	>15	M60^b
Candida parapsilosis	M60^b	4	M60^b	M60^b	14-16	M60^b
Candida tropicalis	M60^b	4	M60^b	M60^b	14-16	M60^b

S = Susceptible; I = Intermediate; R = Resistant
^a Isolates of C. krusei are assumed to be intrinsically resistant to fluconazole and their MICs and/or zone diameters should not be interpreted using this scale.
^b M60 standard is recognized.
^c The term “SDD” is not recognized pending further clarification of the definition of the term by standards development organizations. For isolates testing “I”, doses higher than 6 mg/kg/day should be considered.