Public Health Service investigators have invented a single-mode fiber-optic confocal microscope for which a licensee and commercial developer is sought. The ultrahigh-resolution fiber-optic confocal microscope has an illumination system; three single-mode optical fibers, each optically coupled to a fiber coupler; a sample support stage arranged to receive illumination radiation from an end of one of the single-mode optical fibers; a detector arranged to receive output radiation from one of the single-mode optical fibers; and a lock-in amplifier electrically connected to the detector and the illumination system. The illumination system is adapted to provide illumination radiation that has a time-varying strength correlated with the detector by the lock-in amplifier. The invention provides improved methods and designs for confocal microscopy.

Inventors:
Ilko Ilev
Ronald Waynant
Israel Gannot
Amir Gandjbakhche

Intellectual Property:
U.S. Pat: No. 8,456,738 issued 2013-06-04
PCT Application No. PCT/US2006/014162

Licensing Contact:
Bill Ronnenberg, JD-MIP, MS
FDA Technology Transfer Program
10903 New Hampshire Ave.
Building WO1, Rm 4214
Silver Spring, MD 20993
Email: [email protected]
Phone: 240-402-4561

OTT Reference No: E-2005-006
Updated: August 9, 2015