Research Biologist — Division of Bioinformatics and Biostatistics

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Baitang Ning, Ph.D.
(870) 543-7121
[email protected]  

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About  |  Publications  |  Lab Members

Background

Dr. Baitang Ning received a Ph.D. in molecular biology and biochemistry from the University of Arkansas for Medical Sciences. He joined FDA’s National Center for Toxicological Research (NCTR) as a research biologist in 2002. Dr. Ning has been successful in obtaining and participating in internally and externally funded projects designed to investigate national and international problems of concern to FDA and other collaborating agencies. He participated in writing the FDA Report (Blue Book) on “Paving the Way for Personalized Medicine.” Dr. Ning has received FDA Scientific Achievement Awards for his collaborations and studies and has published 120+ articles and book chapters.  Additionally, he serves/has served as an editorial board member for 8 journals and a reviewer for 80+ journals.

Research Interests

Dr. Ning leads a research team focusing on studies of molecular pharmacogenomics and pharmacoepigenomics in the application of personalized medicine. He has designed, developed, and established in silico, in vivo, in vitro, and molecular pharmacological approaches to identify and evaluate genetic variations and epigenetic mechanisms for inter-individual differences in drug metabolizing enzymes and drug targeting enzymes, which could help FDA reviewers better understand the inter-individual variability of drug efficacy and safety. His research activities align with FDA’s mission and the Critical Path Initiative for personalized medicine.

National and International Groups

FDA Genetics and Genomics Group
NCTR Liaison
2013 – Present

FDA Sequencing Quality Control Group
Sub-project Leader
2012 – Present

Massive Analysis and Quality Control Society
Treasurer
2017 – 2019

Pharmacogenomics Group, American Association of Pharmaceutical Scientists
Chair
2016 – 2017

South Central Chapter of Society of Toxicology
President
2016 – 2017

Select Publications

Biochemical Features and Mutations of Key Proteins in SARS-CoV-2 and Their Impacts on RNA Therapeutics. 
Zeng L., Li D., Tong W., Shi T., and Ning B. 
Biochem Pharmacol. 2021, 19:114424. doi:10.1016/j.bcp.2021.114424.

Long Noncoding RNA Linc00844-Mediated Molecular Network Regulates Expression of Drug Metabolizing Enzymes and Nuclear Receptors in Human Liver Cells.
Li D., Wu L., Knox B., Chen S., Tolleson W.H., Liu F., Yu D., Guo L., Tong W., and Ning B.
Arch Toxicol.  2020, doi:10.1007/s00204/020-02706-5.

Advances and Challenges in Studying Noncoding RNA Regulation of Drug Metabolism and Development of RNA Therapeutics. 
Ning B., Yu D., and Yu A.M.
Biochem Pharmacol. 2019, doi: 10.1016/j.bcp.2019.113638.

Multiple MicroRNA Function as Self-Protective Modules in Acetaminophen-Induced Hepatotoxicity in Humans.
Yu D., Wu L., Gill P., Tolleson W., Chen S., Sun J., Knox B., Jin Y., Xiao W., Hong H., Wang Y., Ren Z., Guo L., Mei N., Guo Y., Yang X., Shi L., Chen Y., Zeng L., Dreval K., Tryndyak V., Pogribny I., Fang H., Shi T., Mccullough S., Bhattacharyya S., Schnackenberg L., Mattes W., Beger R., James L., Tong W., and Ning B.
Arch Toxicol. 2018, 92(2):845-858. doi: 10.1007/s00204-017-2090-y.

A Systematic Evaluation of MicroRNAs in Regulating Human Hepatic CYP2E1.
Wang Y., Yu D., Tolleson W., Yu L., Green B., Zeng L., Chen Y., Chen S., Ren Z., Guo L., Tong W., Guan H., and Ning B.
Biochem Pharmacol. 2017, 138: 174-184. doi: 10.1016/j.bcp.2017.04.020.

MicroRNA hsa-miR-25-3p Suppresses the Expression and Drug Induction of CYP2B6 in Human Hepatocytes.
Jin Y., Yu. D., Tolleson W., Green B., Wang Y., Chen S., Ren Z., Deng H., Guo Y., and Ning B.
Biochem Pharmacol. 2016, pii: S0006-2952(16)30133-2;doi:10.1016/j.bcp.2016.06.007.

Re-Annotation of Presumed Noncoding Disease/Trait-Associated Genetic Variants by Integrative Analyses.
Chen G., Yu D., Chen J., Cao R., Yang J., Wang H., Ji X., Ning B., and Shi T.
Sci Rep. 2015, 5:9453. doi: 10.1038/srep09453.

Suppression of CYP2C9 by MicroRNA hsa-mir-128-3p in Human Liver and Association with Hepatocellular Carcinoma.
Yu D., Green B., Marrone A., Guo Y., Kadlubar S., Lin D., Fuscoe J., Pogribny I., and Ning B.
Sci Rep. 2015, 5: 8534. doi: 10.1038/srep08534.

A Comprehensive Assessment of RNA-Seq Accuracy, Reproducibility and Information Content by the Sequencing Quality Control Consortium.
The SEQC/MAQC-III Consortium.
Nat. Biotechnol. 2014, doi:10.1038/nbt.2957. 

Toxicogenomics and Cancer Susceptibility: Detection by Next-Generation Sequencing.
Ning B., Su Z., Mei N., Hong H., Deng H., Shi L., Fuscoe J., and Tolleson W.
J. Environ. Sci. Health C. 2014, 32(2):121-58. doi:10.1080/10590501.2014.907460.

Gene Expression Variability in Human Hepatic Drug Metabolizing Enzymes and Transporters.
Yang L., Price E., Chang C., Li Y., Huang Y., Guo L., Guo Y., Kaput J., Shi L., and Ning B.
PLoS ONE. 2013, 8(4): e60368. doi:10.1371/journal.pone.0060368.

Similarities and Differences in the Expression of Drug Metabolizing Enzymes Between Human Hepatic Cell Lines and Primary Hepatocytes.
Guo L., Dial S., Shi L., Branham W., Liu J., Fang J., Green B., Deng H., Kaput J., and Ning B.
Drug Metab Dispos. 2011, 39(3):528-38. doi:10.1124/dmd.110.035873.

The MicroArray Quality Control (MAQC)-II Study of Common Practices for the Development and Validation of Microarray-Base Predictive Models.
MAQC Consortium.
Nat Biotechnol. 2010, 228(8):827-38. Doi:10.1038/nbt.1665.

Systematic and Simultaneous Gene Profiling of 84 Drug-Metabolizing Genes in Primary Human Hepatocytes.
Ning B., Dial S., Sun Y., Wang J., and Guo L.
J. Biomol. Screen. 2008, 13(3):194-201.

A Variant of the Cockayne Syndrome B Gene ERCC6 Confers Risk of Lung Cancer.
Lin Z., Zhang Z., Tuo J., Guo Y., Green B., Chan C., Tan W., Huang Y., Ling W., Kadlubar F., Lin D., and Ning B.
Hum. Mut. 2007, doi: 10.1002/humu.20610.

Synergic Effect of Polymorphisms in ERCC6 5' Flanking Region and Complement Factor H on Age-Related Macular Degeneration Predisposition.
Tuo J., Ning B., Bojanowski C., Lin Z., Reed G., Shen D., Jiao X., Chew E., Kadlubar F., and Chan C.
Proceed. Nat. Acad. Sci. 2006, 103:9256-9261.

Common Genetic Polymorphisms in the 5’-Flanking Region of the SULT1A1 Gene: Association of Haplotypes and Platelet Enzymatic Activity.
Ning B., Nowell S., Sweeney C., Ambrosone C., Williams S., Miao X., Liang G., Lin D., Stone A., Ratnasinghe D., Manjanatha M., Lang N., and Kadlubar F.
Pharmacogenet Genomics. 2005,15(7):465-473.

Human Glutathione S-transferase A2 Polymorphisms: Variant Expression, Distribution in Prostate Cancer Cases/Controls and a Novel Form.
Ning B., Wang C., Morel F., Nowell S., Ratnasinghe D., Carter W., Kadlubar F., and Coles B.
Pharmacogenetics. 2004, 14: 35-44.

Increased Transcriptional Activity of the CYP3A4*1B Promoter Variant.
Amirimani B., Ning B., Deitz A., Weber B., Kadlubar F., and Rebbeck T.
Environ. Mol. Mutagen. 2003, 42:299-305. 

Lab Members

Contact information for all lab members:
(870) 543-7121
[email protected] 

Bridgett Knox, B.S.
Biologist

Dongying Li, Ph.D.
Staff Fellow