Research Neurobiologist — Division of Neurotoxicology

Cheng Wang, M.D., Ph.D.
(870) 543-7121
[email protected]  

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About  |  Publications  |  Lab Members

Background

Dr. Cheng Wang has been active in the field of neuroscience research for over 20 years. His educational background includes M.D. and Ph.D. degrees in neurobiology from Geneva University (1996) in Switzerland. Dr. Wang is successful as a principal investigator in obtaining and directing extramural funding for Interagency Agreements designed to allow investigation of problems of national and international scope that are of concern to both FDA and collaborating government agencies. His training and research efforts have been heavily interdisciplinary and have included the subject areas of pharmacology, toxicology, neurobiology, psychiatry, and anesthesiology.

Dr. Wang was awarded the “Outstanding Performance Award” at the Society of Toxicology 44th Annual Meeting and the 2007 “FDA Scientific Achievement Award for Excellence in Laboratory Science.” He also was awarded a 2008 “FDA Group Recognition Award” for his participation in the Pediatric Anesthesia Research Group.

Dr. Wang has published over 80 peer-reviewed research articles in prestigious journals and 14 book chapters. He is a co-editor-in-chief of the book “Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies, and Mechanisms.” He also serves on the editorial board of six reputable journals and as a reviewer for ten other journals.

Research Interests

Dr. Wang is currently responsible for leading a research team that provides unique and highly specialized skills in neurotoxicology, pharmacology, anesthesiology, systems biology, and stem-cell biology research. His specific research interests include neural stem cell biology the application of systems biology in developmental neurotoxicological studies. He is also interested in activity-induced synaptic plasticity and neural-cell adhesion molecule and potential pediatric anesthetic-induced neural cell death and the potential role of neurotransmission (mechanistic studies). Dr. Wang also retains an interest in mitochondrial DNA damage and expression levels of DNA repair enzymes.

Professional Societies/National and International Groups

Society for Neuroscience
Member
2000 – Present

Society of Toxicology
Member
2005 – Present 

Selected Publications

In Vivo Monitoring of Sevoflurane-Induced Adverse Effects in Neonatal Nonhuman Primates Using Small-Animal Positron Emission Tomography.
Zhang X., Liu S., Newport G.D., Paule M.G., Callicott R., Thompson J., Liu F., Patterson T.A., Berridge M.S., Apana S.M., Brown C.C., Maisha M.P., Hanig J.P., Slikker W. Jr., and Wang C.
Anesthesiology. 2016 Jul, 125(1): 133-46; doi: 10.1097/ALN.0000000000001154.

Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage.
Liu F., Rainosek S.W., Frisch-Daiello J.L., Patterson T.A., Paule M.G., Slikker W. Jr., Wang C., and Han X.
Toxicol Sci. 2015 Oct, 147(2): 562-72; doi: 10.1093/toxsci/kfv150.

Protective Effect of Acetyl-L-Carnitine on Propofol-Induced Toxicity in Embryonic Neural Stem Cells.
Liu F., Rainosek S.W., Sadovova N., Fogle C.M., Patterson T.A., Hanig J.P., Paule M.G., Slikker W. Jr., and Wang C.
Neurotoxicology. 2014 May, 42: 49-57; doi: 10.1016/j.neuro.2014.03.011.

A Minimally Invasive, Translational Biomarker of Ketamine-Induced Neuronal Death in Rats: Micropet Imaging Using 18F-Annexin V.
Zhang X., Paule M.G., Newport G.D., Zou X., Sadovova N., Berridge M.S., Apana S.M., Hanig J.P., Slikker W. Jr., and Wang C.
Toxicol Sci. 2009 Oct, 111(2): 355-61.

Strategies and Experimental Models for Evaluating Anesthetics: Effects on the Developing Nervous System.
Wang C., and Slikker W. Jr.
Anesth Analg. 2008 Jun, 106(6): 1643-58.

Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey.
Slikker W. Jr., Zou X., Hotchkiss C.E., Divine R.L., Sadovova N., Twaddle N.C., Doerge D.R., Scallet A.C., Patterson T.A., Hanig J.P., Paule M.G., and Wang C.
Toxicol Sci. 2007 Jul, 98(1): 145-58.

Blockade of N-Methyl-D-Aspartate Receptors by Ketamine Produces Loss Of Postnatal Day 3 Monkey Frontal Cortical Neurons in Culture.
Wang C., Sadovova N., Hotchkiss C., Fu X., Scallet A.C., Patterson T.A., Hanig J., Paule M.G., and Slikker W. Jr.
Toxicol Sci. 2006 May, 91(1): 192-201.

Blockade of N-Methyl-D-Aspartate Receptors by Phencyclidine Causes the Loss of Corticostriatal Neurons.
Wang C., Anastasio N., Popov V., Leday A., and Johnson K.M.
Neuroscience. 2004, 125(2): 473-83.

Functional N-Methyl-D-Aspartate Receptors in O-2A Glial Precursor Cells: A Critical Role in Regulating Polysialic Acid-Neural Cell Adhesion Molecule Expression and Cell Migration.
Wang C., Pralong W.F., Schulz M.F., Rougon G., Aubry J.M., Pagliusi S., Robert A., and Kiss J.Z.
J Cell Biol. 1996 Dec, 135(6 Pt 1): 1565-81.

PSA-NCAM is Required for Activity-Induced Synaptic Plasticity.
Muller D., Wang C., Skibo G., Toni N., Cremer H., Calaora V., Rougon G., and Kiss J.Z.
Neuron. 1996 Sep, 17(3): 413-22.

Requirement of Polysialic Acid for the Migration of the O-2A Glial Progenitor Cell from Neurohypophyseal Explants.
Wang C., Rougon G., and Kiss J.Z.
J Neurosci. 1994 Jul, 14(7): 4446-57.

Lab Members

Contact information for all lab members:
(870) 543-7121
[email protected]  
 

Fang Liu, Ph.D.
Staff Fellow

Shuliang Liu, Ph.D.
Staff Fellow

Qi Yin, Ph.D.
Postdoctoral Fellow 

Xuan Zhang, Ph.D.
Staff Fellow