Research Biologist — Division of Biochemical Toxicology

Igor Pogribny, M.D., Ph.D.
(870) 543-7121
[email protected]  

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 About  |  Publications  |  Lab Members

Background

Dr. Igor Pogribny received an M.D. in 1982 and a Ph.D. in biochemistry and oncology in 1986 in the Ukraine and joined NCTR in 1999. He is the recipient of the FDA “Outstanding Service Award” (2006) and FDA “Commissioner’s Special Citation Award” (2011).

Research Interests

Dr. Pogribny’s research interests and experience are centered in three major areas: 1) to elucidate the role and significance of genetic and epigenetic alterations in the development and progression of cancer, 2) to investigate and establish the role of epigenetic alterations as indicators of exposure to genotoxic and non-genotoxic carcinogens ─ critical for the primary prevention of neoplasia in humans, and 3) to conduct research on nonalcoholic fatty liver disease (NAFLD).

NAFLD is strongly associated with metabolic syndrome and obesity. It includes a range of liver injury from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis, and is a major health problem and leading cause of chronic liver disease in the United States and Western countries. Dr. Pogribny’s laboratory aims to better understand the role of individual genetic and genomic ─ including epigenomic ─ susceptibility factors in the development of NAFLD.  Identification of these susceptibility factors may facilitate the development of diagnostic tools that can be used to identify high-risk individuals to help prevent NAFLD-related liver cancer.

Professional Societies/National and International Groups

American Association for Cancer Research
Member
2012 – Present

Society of Toxicology
Member
2012 – Present

Selected Publications

Furan-Induced Transcriptomic and Gene-Specific DNA Methylation Changes in the Livers Of Fischer 344 Rats in a 2-Year Carcinogenicity Study.
Tryndyak V, de Conti A, Doerge D, Olson GR, Beland FA, Pogribny IP.
Arch Toxicol. 2016, [in press].
 
Irreversible Down-Regulation of mir-375 in the Livers of Fischer 344 Rats after Chronic Furan Exposure.
de Conti A, Tryndyak V, Doerge DR, Beland FA, Pogribny IP. 
Food Chem Toxicol. 2016, pii: S0278-6915(16)30207-1.

Differentially Expressed MicroRNAs Provide Mechanistic Insight into Fibrosis-Associated Liver Carcinogenesis in Mice.
Marrone AK, Shpyleva S, Chappell G, Tryndyak V, Uehara T, Tsuchiya M, Beland FA, Rusyn I, Pogribny IP.
Mol Carcinog. 2016, 55(5):808-17.

Epigenetic Alterations Induced by Genotoxic Occupational and Environmental Human Chemical Carcinogens: A Systematic Literature Review.
Chappell G, Pogribny IP, Guyton KZ, Rusyn I.
Mutat Res Rev Mutat Res. 2016, 768:27-45.

Status of Hepatic DNA Methylome Predetermines and Modulates the Severity of Non-Alcoholic Fatty Liver Injury in Mice.
Tryndyak VP, Han T, Fuscoe JC, Ross SA, Beland FA, Pogribny IP.
BMC Genomics. 2016, 17:298.

MicroRNA Changes, Activation of Progenitor Cells, and Severity of Liver Injury in Mice Induced by Choline and Folate Deficiency.
Tryndyak VP, Marrone AK, Latendresse JR, Muskhelishvili L, Beland FA, Pogribny IP.
J Nutr Biochem. 2016, 28:83-90.

MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[A]Pyrene In Human HepaRG Cells.
Marrone AK, Tryndyak V, Beland FA, Pogribny IP. 
Toxicol Sci. 2016, 149(2):496-502.

The Role of MicroRNAs in the Development and Progression of Chemical-Associated Cancers.
Pogribny IP, Beland FA, Rusyn I.
Toxicol Appl Pharmacol. 2015, pii: S0041-008X(15)30140-X.

Persistence of Furan-Induced Epigenetic Aberrations in the Livers of F344 Rats.
de Conti A, Kobets T, Tryndyak V, Burnett SD, Han T, Fuscoe JC, Beland FA, Doerge DR, Pogribny IP. 
Toxicol Sci. 2015, 144(2):217-26.

Genetic and Epigenetic Changes in Fibrosis-Associated Hepatocarcinogenesis in Mice.
Chappell G, Kutanzi K, Uehara T, Tryndyak V, Hong H-H, Hoenerhoff M, Beland FA, Rusyn I, Pogribny IP.
Int J Cancer. 2014, 134(12):2778-88.

Lab Members

Contact Information for all lab members:
(870) 543-7121
[email protected]

Aline de Conti, Ph.D.
Staff Fellow

Mekonnen Lemma Dechassa, Ph.D.
Commissioner Fellow

Kostiantyn Dreval, Ph.D.
ORISE Postdoctoral Fellow

Volodymyr Tryndyak, Ph.D.
Senior Staff Fellow