A-TRAC TCORS Project 1: Cardiovascular Toxicity of Tobacco Products

Principal Investigators: Daniel Joseph Conklin

Funding Mechanism: National Institutes of Health – TCORS Grant

ID number: 2 U54 HL120163-06

Award Date: 8/31/18

Institution: University of Louisville

Cardiovascular disease (CVD), including coronary heart disease and stroke, is the leading causes of death and disability associated with tobacco use. However, more information would be useful regarding specific tobacco product constituents that affect cardiovascular toxicity. The goal of this American Heart Association Tobacco Center for Regulatory Science (A-TRAC) project is to test the hypothesis that cardiovascular injury due to tobacco product use could be attributed mostly to volatile organic compounds (VOCs; e.g., formaldehyde, acetaldehyde, acrolein, benzene, xylene) generated in a variety of tobacco products. Study aims are: (1) to quantify the cardiovascular toxicity of tobacco product-derived VOCs in human cells in vitro; (2) to assess short-term and chronic toxicity of tobacco products (i.e., combustible cigarettes, smokeless tobacco, electronic nicotine delivery systems, electronic and conventional hookah) using a mouse model; and, (3) to identify individual VOCs that mediate the cardiovascular toxicity of tobacco products. To test this hypothesis, researchers will define the contribution of VOCs to the cardiovascular toxicity of tobacco products using sensitive and informative in vitro assays and well-controlled animal exposures. Findings will provide new information related to the cardiovascular toxicity of tobacco products and their constituents to inform future regulatory activities.

U.S. Food and Drug Administration

A-TRAC TCORS Project 1: Cardiovascular Toxicity of Tobacco Products

A-TRAC TCORS American Heart Association Tobacco Center for Regulatory Science 2.0: Related Resources