Yale Tobacco Center of Regulatory Science
Principal Investigator: Suchitra Krishnan-Sarin and Stephanie O'Malley
Funding Mechanism: National Institutes of Health- TCORS Grant
ID number: 1P50DA036151-01
Award Date: 9/30/2013
Institution: Yale University
The Center will conduct research to evaluate how flavors (including menthol), sweeteners, and related factors affect the initiation of, preference for, and development of addiction to current tobacco and potential modified risk tobacco products. Populations studied will include adolescent and adult mice and rats, adolescent and young adult smokers and nonsmokers, and chronic smokers. Project 1 will study the effects of flavors on nicotine choice and dopaminergic/central reward mechanisms in mice and rat models. Project 2 will study menthol’s effects on nicotine reinforcement in smokers. Project 3 will evaluate whether commonly used flavor constituents, including menthol, alter reinforcement from e-cigarettes in adolescent smokers. Project 4 will examine factors (including product attributes and informal/formal sources of information about risks) that influence both the perceptions of risk and interest in using tobacco products in different populations (i.e. populations that vary by age, race, smoking status, and socioeconomic status).
Yale Tobacco Center of Regulatory Science (TCORS) Related Resources
- Additional Information can be found at the National Institute of Health
- Project 1: Effects of Flavors on Nicotine Choice and Central Reward Mechanisms
- Project 2: Menthol's Effects on the Nicotine Reinforcement in Smokers
- Project 3: Flavors and E-cigarette Effects in Adolescent Smokers
- Project 4: Economics, Experiments and PATH Data: Creating Knowledge for Tobacco Regulation