Conference

Event Title

23rd US-Japan Cellular and Gene Therapy Conference

March 12, 2020

Postponed

Date:: March 12, 2020
Time:: 8:30 AM - 5:00 AM ET
Location:: Event Location

FDA, White Oak Campus, The Great Room
Building 31

10903 New Hampshire Avenue
Silver Spring, MD 20903
United States

Organized By:: Organizer

Center for Biologics Evaluation and Research (CBER)

Due to extenuating circumstances, this conference is being postponed until further notice.

Exosomes in Cancer Treatments and Other Diseases

FDA White Oak Campus, Building 31, Great Room, 1503 A
Silver Spring, Maryland 20993

Thursday, March 12, 2020

8:30 am – 5:00 pm

Cover Image: Exosomes secreted by cancer cells; Source: Cancer Research from Technology Networks.

The annual US-Japan Cellular and Gene Therapy Conference will provide scientists from Japan and the U.S. a valuable opportunity to discuss the state of the art of exosome therapies and establish research collaborations.

The conference is jointly supported by the Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA), and the Ministry of Education, Culture, Sports, Science and Technology, Japan under the US-Japan Cooperative Research Program.

Exosomes are of immense biological interest due to their pleiotropic nature. These nanosized, single-membrane biovesicles are secreted by normal and diseased cells--including neoplastic cells--into blood and body fluids. They mediate intercellular communication by carrying different biomolecules, including proteins, lipids, and genetic materials, such as RNA. Exosomes appear to play roles in many physiological processes, such as cancer stemness, angiogenesis, metastasis, and immune response modulation. However, while several clinical studies of exosomes are underway, their quality attributes are not fully understood.

The speakers will discuss the mechanism of exosome biogenesis, molecular composition of exosomes, technologies used in exosomes isolation, mechanisms of action, and their translational potential. The program is designed to advance understanding of the therapeutic potential of exosomes and help to resolve the obstacles to their full clinical application.

No prior registration is required. Attendance is free and open to the public. For more information, please contact S. Rafat Husain at [email protected] or (240) 402-9598.

The event can be viewed live via Adobe Connect at https://collaboration.fda.gov/us-japan/. Click the link and enter as a guest. Driving directions and visitors parking information is available at
https://www.fda.gov/AboutFDA/WorkingatFDA/BuildingsandFacilities/WhiteOakCampusInformation/ucm241748.htm

PROGRAM
8:30 am – 9:00 am	Registration, Coffee and Breakfast
*Moderator*	S. Rafat Husain, Staff Scientist, Division of Cellular and Gene Therapies, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland
Opening Remarks
9:00 am – 9:05 am	Peter Marks, Director, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland
9:05 am – 9:10 am	Yoshikazu Ohya, Professor, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo
Morning Session
*Moderators*	Akiko Takahashi, Project Leader, Project for Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research / PRESTO, JST Saitama Japan, PRIME, AMED, Tokyo, Japan
	Raj K. Puri, Director, Division of Cellular and Gene Therapies, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland
9:10 am – 9:40 am	*The biology of cellular senescence and small extracellular vesicles* Akiko Takahashi, Project Leader, Project for Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research / PRESTO, JST Saitama Japan, PRIME, AMED, Tokyo
9:40 am – 10:10 am	*Exosome biogenesis and exosome engineering* Stephen J. Gould, Co-Director, Graduate Program in Biological Chemistry, Professor, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland
10:10 am – 10:30 am	Coffee Break
10:30 am – 11:00 am	*Hippo pathway in cancer and immunity* Toshiro Moroishi, Professor, Department of Cell Signaling and Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
11:00 am – 11:30 am	*Circadian variation in urine exosome excretion: implications for biomarker normalization* Peter Yuen, Staff Scientist, Renal Diagnostics and Therapeutics Unit, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland
11:30 am – 12:00 pm	*Early-stage cancer diagnoses using microRNA ensemble biomarkers in urine* Takao Yasui, Associate Professor, Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University; PRESTO, Japan Science and Technology Agency (JST), Japan
12:00 pm – 1:00 pm	Lunch
Afternoon Session
*Moderators*	Takahiko Tokuda, Professor, Department of Molecular Pathobiology of Brain Diseases, Kyoto Prefectural University of Medicine, Kyoto, Japan
	Lance Liotta, Co-Director and Co-Founder, Center for Applied Proteomics and Molecular Medicine, School of Systems Biology, George Mason University Virginia, Fairfax, Virginia
1:00 pm – 1:30 pm	Engineering EVs to reverse cancer immune evasion at the level of the sentinel lymph node Lance Liotta, Co-Director and Co-Founder, Center for Applied Proteomics and Molecular Medicine, School of Systems Biology, George Mason University, Virginia, Fairfax, Virginia
1:30 pm – 2:00 pm	*Exosomes as double-edged sword for cancer metastasis promotion* Marta Prieto Vila, Assistant Professor, Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan
2:00 pm – 2:30 pm	*Damage and Repair: How "Bad EVs" from infections cause death and "Good EVs" from Stem cells do repair* Fatah Kashanchi, Professor and Director, Laboratory of Molecular Virology, School of Systems Biology , George Mason University, Virginia, Fairfax, Virginia
2:30 pm – 2:50 pm	Coffee Break
2:50 pm – 3:20 pm	*Development of blood-based biomarkers for neurodegenerative diseases* Takahiko Tokuda, Professor, Department of Molecular Pathobiology of Brain Diseases, Kyoto Prefectural University of Medicine, Kyoto, Japan
3:20 pm – 3:50 pm	*Engineering extracellular vesicle potency and production for therapeutic applications* Steven Jay, Associate Professor, Fischell Department of Bioengineering, University of Maryland, College Park, Maryland
3:50 pm – 4:20 pm	*Propagation of TDP-43 as a key factor of disease progression of amyotrophic lateral sclerosis* Yohei Iguchi, Assistant Professor, Department of Neurology, Graduate School of Medicine, Nagoya University
4:20 pm - 4:50 pm	*Developing a toolset to characterize EVs in a translational setting* Joshua Welsh, CRTA Fellow, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, NIH, Bethesda, Maryland
Thank you for your participation!
Organizers:	S. Rafat Husain, Ph.D. Raj K Puri, M.D., Ph.D. Tumor Vaccines and Biotechnology Branch Division of Cellular and Gene Therapies WO52/72 Rm 3123, 10903 New Hampshire Av. Silver Spring, MD 20993-0002 Ph. 240-402-9598; Fax 301-595-1093 [email protected] [email protected]	Yoshikazu Ohya, Ph.D. Professor, Division of Biosciences Department of Integrated Biosciences Graduate School of Frontier Sciences University of Tokyo Bldg. FSB-101, 5-1-5 Kashiwanoha Kashiwa, Chiba Prefecture 277-8562 Japan [email protected]
Cover Image: Exosomes secreted by cancer cells. Source: Cancer Research from Technology Networks