Division of Emerging Technologies

Biography

Dr. Harrison is a Research Microbiologist at the Division of Emerging Technologies in the Office of Applied Science at the Center for Veterinary Medicine, U.S. Food and Drug Administration.  He received his Ph.D. in Medical Microbiology and Immunology from the Creighton University School of Medicine in 2019.  Shortly after, Dr. Harrison joined the FDA Center for Veterinary Medicine as a Staff Fellow where he employed genomic analyses to help inform source attribution studies.  Currently, he researches trends in antimicrobial resistance in foodborne pathogens for the National Antimicrobial Resistance Monitoring System (NARMS) program. 

Research

• Develops tools to better characterize mobile genetic elements that carry antimicrobial resistance and virulence genes
• Investigates associations between antimicrobial resistance genes and various isolation sources using the genomic data of foodborne pathogens
• Employs molecular techniques to evaluate the contributions of individual antimicrobial resistance genes in foodborne pathogens

Select Publications

Harrison, L., Zhao, S., Li, C., McDermott, P.F., Tyson, G.H. and Strain, E., 2023. Lociq provides a loci-seeking approach for enhanced plasmid subtyping and structural characterization. Communications Biology, 6(1), p.595.

Harrison, L., Tyson, G.H., Strain, E., Lindsey, R.L., Strockbine, N., Ceric, O., Fortenberry, G.Z., Harris, B., Shaw, S., Tillman, G., Zhao, S. and Dessai, U., 2022. Use of Large-Scale Genomics to Identify the Role of Animals and Foods as Potential Sources of Extraintestinal Pathogenic Escherichia coli That Cause Human Illness. Foods, 11(13), p.1975.

Tyson, G.H., Li, C., Harrison, L.B., Martin, G., Hsu, C.H., Tate, H., Tran, T.T., Strain, E. and Zhao, S., 2021. A multidrug-resistant Salmonella Infantis clone is spreading and recombining in the United States. Microbial Drug Resistance, 27(6), pp.792-799.

Li, C., Tyson, G.H., Hsu, C.H., Harrison, L., Strain, E., Tran, T.T., Tillman, G.E., Dessai, U., McDermott, P.F. and Zhao, S., 2021. Long-read sequencing reveals evolution and acquisition of antimicrobial resistance and virulence genes in Salmonella enterica. Frontiers in Microbiology, 12.

Harrison, L., Mukherjee, S., Hsu, C.H., Young, S., Strain, E., Zhang, Q., Tillman, G.E., Morales, C., Haro, J. and Zhao, S., 2021. Core Genome MLST for Source Attribution of Campylobacter coli. Frontiers in Microbiology, p.1936.

Hsu, C.H., Harrison, L., Mukherjee, S., Strain, E., McDermott, P., Zhang, Q. and Zhao, S., 2020. Core genome multilocus sequence typing for food animal source attribution of human Campylobacter jejuni infections. Pathogens, 9(7), p.532.

Harrison, L.B., Fowler, R.C., Abdalhamid, B., Selmecki, A. and Hanson, N.D., 2019. lptG contributes to changes in membrane permeability and the emergence of multidrug hypersusceptibility in a cystic fibrosis isolate of Pseudomonas aeruginosa. MicrobiologyOpen, 8(11), p.e844.

Harrison, L.B. and Hanson, N.D., 2017. High-resolution melting analysis for rapid detection of sequence type 131 Escherichia coli. Antimicrobial agents and chemotherapy, 61(6), pp.10-1128.