Visiting Scientist —  Division of Biochemical Toxicology

Miao Li, Ph.D., Master of Medicine, DABT
(870) 543-7121
[email protected]  

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 About  |  Publications  |  Lab Members
 

Background

Dr. Miao Li graduated from Huazhong University of Science and Technology Tongji Medical College with a bachelor’s degree in pharmaceutics, followed by a master’s degree in hygiene inspection and quarantine. He then received a Ph.D. in toxicology from the University of Iowa. Dr. Li completed his postdoctoral training at the Institute of Computational Comparative Medicine at Kansas State University with a research focus on physiologically based pharmacokinetic (PBPK) modeling for food safety assessment. He joined FDA’s National Center for Toxicological Research (NCTR) in the Division of Biochemical Toxicology in 2019 and has been a board-certified toxicologist since 2019.

Research Interests

Dr. Li’s research mainly focuses on the development and application of PBPK modeling to support therapeutic dose adjustment and chemical risk assessment. His research interests include life-stage modeling, in vitro to in vivo extrapolation, population modeling, model parameter analysis, and model extrapolation across species. Dr. Li uses life-stage PBPK models to ensure drug safety and efficacy, applies in vitro to in vivo extrapolation to determine model parameter values, and uses population modeling to simulate variabilities in patients. Currently, he is working on developing perinatal life-stage PBPK models for COVID-19 therapeutics to support dosage adjustment. Dr. Li is skilled in pharmacokinetic data analysis and developing PBPK models with commercial software or programming languages.

Professional Societies/National and International Groups

American Board of Toxicology
Diplomate
2019 – Present

Society of Toxicology (SOT)
Member
2012 – Present

Biological Modeling Specialty Section, SOT
Secretary and Treasurer 
2020 – 2022

Risk Assessment Specialty Section, SOT
Councilor
2021 – 2023

Selected Publications

Physiologically Based Pharmacokinetic (PBPK) Modeling of RNAi Therapeutics: Opportunities and Challenges.
Fairman K., Li M., Ning B., and Lumen A.
Biochem Pharmacol. 2021, 189:114468. doi: 10.1016/j.bcp.2021.114468 [Epub 2021 Feb 10].

Physiological Parameter Values for Physiologically Based Pharmacokinetic Models in Food-Producing Animals. Part III: Sheep and Goat.
Li M., Wang Y.S., Elwell-Cuddy T., Baynes R.E., Tell L.A., Davis J.L., Maunsell F.P., Riviere J.E., and Lin Z.
J Vet Pharmacol Ther.2021, 44(4):456-477. doi: 10.1111/jvp.12938. [Epub 2020 Dec 22.].

Physiologically Based Pharmacokinetic Modeling: A Promising Tool for Translational Research and Regulatory Toxicology.
Fairman K., Li M., Kabadi S.V., and Lumen A.
Current Opinion in Toxicology. 2020, 23-24:17-22; doi: 10.1016/j.cotox.2020.03.001.

Physiologically Based Pharmacokinetic Model Calibration, Evaluation, and Performance Assessment.
Lin Z., Cheng Y.H., Chou W.C., and Li M.
In: Fisher J., Gearhart J., and Lin Z., eds.
Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment. 2020, 243-279, doi: 10.1016/B978-0-12-818596-4.00010-2.

Physiological Parameter Values for Physiologically Based Pharmacokinetic Models in Food-Producing Animals. Part I: Cattle and Swine.
Lin Z., Li M., Wang Y.S., Tell L.A., Baynes R.E., Davis J.L., Vickroy T.W., and Riviere J.E.
J Vet Pharmacol Ther. 2020, 43(5):385-420. doi: 10.1111/jvp.12861. [Epub 2020 Apr 8.].

Development and Application of a Population Physiologically Based Pharmacokinetic Model for Penicillin G in Swine and Cattle for Food Safety.
Li M., Gehring R., Riviere J.E., and Lin Z.
Food Chem Toxicol. 2017, 107(Pt A):74-87. doi: 10.1016/j.fct.2017.06.023. [Epub 2017 Jun 13.].

Cytochrome c Adducts with PCB Quinoid Metabolites.
Li M., Teesch L.M., Murry D.J., Pope R.M., Li Y., Robertson L.W., and Ludewig G.
Environ Sci Pollut Res Int. 2016, 23(3):2148-59. doi: 10.1007/s11356-015-4801-3. [Epub 2015 Jun 12.].

Does Dietary Copper Supplementation Enhance or Diminish PCB126 Toxicity in the Rodent Liver?
Lai I.K., Klaren W.D., Li M., Wels B., Simmons D.L., Olivier A.K., Haschek W.M., Wang K., Ludewig G., and Robertson L.W.
Chem Res Toxicol. 2013, 26(5):634-44. doi: 10.1021/tx400049s. [Epub 2013 Apr 15.].

Glia Activation Induced by Peripheral Administration of Aluminum Oxide Nanoparticles in Rat Brains.
Li X., Zheng H., Zhang Z., Li M., Huang Z., Schluesener H.J., Li Y., and Xu S.
Nanomedicine. 2009, 5(4):473-9. doi: 10.1016/j.nano.2009.01.013. [Epub 2009 Feb 13.].

Lab Members

Contact information for all lab members:
(870) 543-7121
[email protected]

Kiara Fairman, Pharm.D.
Staff Fellow

Me-Kyoung Choi, Pharm.D.
ORISE Fellow

Pavani Gonnabathula, Ph.D.
ORISE Fellow