Staff Fellow — Division of Neurotoxicology

Fang Liu, Ph.D.
(870) 543-7391
NCTRResearch@fda.hhs.gov  

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About  |  Publications  |  Lab Members

Background

Dr. Fang Liu received her bachelor’s degree in clinical medicine and her master’s degree in medicine from Hebei Medical University, China. She then earned her Ph.D. in biomedical sciences from the University of Montreal, Canada. Dr. Liu was a faculty member at the Hebei Medical University in China for approximately 10 years. She began working as a staff fellow in the Division of Neurotoxicology at NCTR after completing her post-doctoral training at NCTR. She has been actively involved in biomedical research and has been an author and co-author on more than 50 peer-reviewed scientific articles and book chapters in areas such as toxicology, molecular biology, histology and pathology, and genomics.

Research Interests

Dr. Liu has been working on understanding the adverse effects of chemical exposures on the central and peripheral nervous system. Currently, there is public concern as to whether general anesthetics can cause adverse effects on pediatric patients. To support FDA’s mission to properly regulate the use of general anesthetics in young children, Dr. Liu focuses her research on understanding the effects of general anesthetics on the developing central nervous system, using various models. In recent years, she has employed neural stem cells which can recapitulate many important developmental procedures of the brain in vitro to study the developmental neurotoxicity of general anesthetics.

Professional Societies/National and International Groups

Arkansas Neural Stem Cell Coalition
Member
2011 – Present

Society for Neuroscience (and the Arkansas Chapter of the Society for Neuroscience)
Member
2011 – Present

Society of Toxicology
Member
2011 – Present

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Selected Publications

In Vivo Monitoring of Sevoflurane-Induced Adverse Effects in Neonatal Nonhuman Primates Using Small-Animal Positron Emission Tomography.
Zhang X., Liu S., Newport G.D., Paule M.G., Callicott R., Thompson J., Liu F., Patterson T.A., Berridge M.S., Apana S.M., Brown C.C., Maisha M.P., Hanig J.P., Slikker W. Jr., and Wang C.
Anesthesiology. 2016 Jul, 125(1): 133-46.

Relationship between Ketamine-Induced Developmental Neurotoxicity and NMDA Receptor-Mediated Calcium Influx in Neural Stem Cell-Derived Neurons.
Wang C., Liu F., Patterson T.A., Paule M.G., and Slikker W. Jr.
Neurotoxicology. 2016 Apr, doi: 10.1016/j.neuro.2016.04.015.

Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage.
Liu F., Rainosek S.W., Frisch-Daiello J.L., Patterson T.A., Paule M.G., Slikker W. Jr., Wang C., and Han X.
Toxicol Sci. 2015 Oct, 147(2): 562-72

Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells.
Slikker W. Jr., Liu F., Rainosek S.W., Patterson T.A., Sadovova N., Hanig J.P., Paule M.G., and Wang C.
Mol Neurobiol. 2015 Oct, 52(2): 959-69.

Mechanisms of Tolvaptan-Induced Toxicity in HepG2 Cells.
Wu Y., Beland F.A., Chen S., Liu F., Guo L., and Fang J.L.
Biochem Pharmacol. 2015 Jun, 95(4): 324-36.

Effects of Silver Nanoparticles on Human and Rat Embryonic Neural Stem Cells.
Liu F., Mahmood M., Xu Y., Watanabe F., Biris A.S., Hansen D.K., Inselman A., Casciano D., Patterson T.A., Paule M.G., Slikker W. Jr., and Wang C.
Front Neurosci. 2015 Apr, 9: 115.

The Role of Autophagy in Usnic Acid-Induced Toxicity in Hepatic Cells.
Chen S., Dobrovolsky V.N., Liu F., Wu Y., Zhang Z., Mei N., and Guo L.
Toxicol Sci. 2014 Nov, 142(1): 33-44.

Protective Effect of Acetyl-L-Carnitine on Propofol-Induced Toxicity in Embryonic Neural Stem Cells.
Liu F., Rainosek S.W., Sadovova N., Fogle C.M., Patterson T.A., Hanig J.P., Paule M.G., Slikker W. Jr., and Wang C.
Neurotoxicology. 2014 May, 42: 49-57.

Utilization of Neural Stem Cell-Derived Models to Study Anesthesia-Related Toxicity and Preventative Approaches.
Wang C., Liu F., Patterson T.A., Paule M.G., Slikker W. Jr.
Mol Neurobiol. 2013 Oct, 48(2): 302-7.

Ketamine-Induced Neuronal Damage and Altered N-Methyl-D-Aspartate Receptor Function in Rat Primary Forebrain Culture.
Liu F., Patterson T.A., Sadovova N., Zhang X., Liu S., Zou X., Hanig J.P., Paule M.G., Slikker W. Jr., and Wang C.
Toxicol Sci. 2013 Feb, 131(2): 548-57.

Phototoxicity of Kava - Formation of Reactive Oxygen Species Leading to Lipid Peroxidation and DNA Damage.
Xia Q., Chiang H.M., Zhou Y.T., Yin J.J., Liu F., Wang C., Guo L., and Fu P.P.
Am J Chin Med. 2012, 40(6): 1271-88.

Inhalation Anesthetic-Induced Neuronal Damage in the Developing Rhesus Monkey.
Zou X., Liu F., Zhang X., Patterson T.A., Callicott R., Liu S., Hanig J.P., Paule M.G., Slikker W. Jr., and Wang C.
Neurotoxicol Teratol. 2011 Sep-Oct, 33(5): 592-7.

Changes in Gene Expression after Phencyclidine Administration in Developing Rats: A Potential Animal Model for Schizophrenia.
Liu F., Zou X., Sadovova N., Zhang X., Shi L., Guo L., Qian F., Wen Z., Patterson T.A., Hanig J.P.,  Paule M.G., Slikker W. Jr., and Wang C.
Int J Dev Neurosci. 2011 May, 29(3):351-8.

Ketamine Anesthesia during the First Week of Life can Cause Long-Lasting Cognitive Deficits in Rhesus Monkeys.
Paule M.G., Li M., Allen R.R., Liu F., Zou X., Hotchkiss C., Hanig J.P., Patterson T.A., Slikker W. Jr., and Wang C.
Neurotoxicol Teratol. 2011 Mar-Apr, 33(2): 220-30.

Ketamine-Induced Neurotoxicity and Changes in Gene Expression in the Developing Rat Brain.
Liu F., Paule M.G., Ali S., and Wang C.
Curr Neuropharmacol. 2011 Mar, 9(1): 256-61.

Anesthetic-Induced Oxidative Stress and Potential Protection.
Wang C., Zhang X., Liu F., Paule M.G., and Slikker W. Jr.
ScientificWorldJournal. 2010 Jul, 10: 1473-82.

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Lab Members

Contact information for all lab members:
(870) 543-7391
NCTRResearch@fda.hhs.gov  

C. Matthew Fogle, B.S.
Research Biologist

Shuliang Liu, Ph.D.
Visiting Scientist

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