Staff Fellow — Division of Microbiology

Jing Han, Ph.D.
(870) 543-7121
NCTRResearch@fda.hhs.gov  

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 About  |  Publications 

Background

Dr. Jing Han is a research microbiologist/staff fellow in the Division of Microbiology at NCTR. Dr. Han’s academic career dates back to her years in China, where she received her Bachelor of Science degree in veterinary medicine from Shandong Agricultural University and her Master of Science degree in veterinary microbiology and preventive medicine from China Agricultural University. Her research focused mainly on the development of an ALV (Avian Leukosis Virus) detection kit. As one of the key players, she expressed and purified the ALV P27 protein, then developed mouse anti-P27 monoclonal antibodies and rabbit anti-P27 polyclonal antibodies using the purified P27 as antigen. Using the monoclonal antibodies and polyclonal antibodies that Dr. Han developed, an ALV detection kit was developed and has been commercialized in China. It is used extensively by poultry farms to detect virus antigens and antibodies in serum or egg samples. After receiving her MS degree, Dr. Han pursued her Ph.D. in veterinary microbiology at Iowa State University. The focus of her research was on the identification of novel mechanisms involved in the emergence and fitness of fluoroquinolone (FQ)–resistant Campylobacter. In 2009, Dr. Han earned her Ph.D. in veterinary microbiology from Iowa State University in Ames. Following the defense of her doctoral dissertation, she joined Dr. Steve Foley’s lab at NCTR as a postdoctoral fellow and conducted research related to understanding the mechanisms that facilitate the spread and persistence of virulent and antimicrobial-resistant bacteria. Following her postdoctoral fellowship, Dr. Han joined the Public Health Laboratory of Arkansas Department of Health as a microbiologist, where she conducted microbiological testing and interpretation of results as well as data analyses. In 2015, Dr. Han rejoined NCTR as a research microbiologist where she served as a leading investigator on a project funded by FDA’s Center for Tobacco Products (CTP) focusing on smokeless tobacco-associated microbiology. Currently she is serving as the Principal Investigator (PI) of an NCTR protocol that aims to develop improved databases to 1) identify Salmonella-virulence genes, 2) characterize plasmids, and 3) develop the analytical tools for Whole Genome Sequencing (WGS) data analyses.

Research Interests

Dr. Han’s main research interests are in the fields of antimicrobial resistance, pathogenesis of foodborne pathogens, and genetic characterization of enteric bacteria using molecular techniques. Her research projects at NCTR include:

• genetic characterization of antimicrobial resistance and associated genetic factors in Salmonella Serovars associated with food animals and invasive human infections
• sequencing and functional analysis of plasmids isolated from multi-antimicrobial resistant bacteria
• evaluation of the relative selective potential of antimicrobial agents to trigger the dissemination of antimicrobial resistance and virulence factors to susceptible Salmonella.
• investigation of both the microbial populations and the development of tobacco specific nitrosamines in moist snuff products funded by CTP.

Dr. Han has used different approaches (culture-based, molecular, and bioinformatics approaches) to identify and characterize the bacterial and fungal populations in smokeless tobacco products and evaluate their potential to contribute to carcinogen formation.
 

Professional Societies/National and International

American Society for Microbiology
Member
2007 – Present
 

Selected Publications

Impact of Co-Carriage of IncA/C Plasmids with Additional Plasmids on the Transfer of Antimicrobial Resistance in Salmonella Enterica Isolates.
Han J., Pendleton S., Deck J., Singh R., Gilbert J., Johnson T., Sanad Y., Nayak R., and Foley S.
Int. J. Food Microbiol. 2018, 271:77-84.
 

Evaluation of the Genetics and Functionality of Incompatibility 1 (IncI1) Plasmids from Salmonella Enterica.
Kaldhone P., Han J., Deck J., Khajanchi B., Nayak R., Foley S., and Ricke S.
Foodborne Path. Dis. 2018, 15(3):168-176.

Cj1199 Affect the Development of Erythromycin Resistance in Campylobacter Jejuni Through Regulation of Leucine Biosynthesis. 
Hao H., Li F., Han J., Foley SL., Dai M., Wang X., Wang Y., Huang L., Sun Y., Liu Z., and Yuan Z.
Front. Microbiol. 2017, 8:16.
 

Bacterial Populations Associated with Smokeless Tobacco Products.
Han J., Sanad Y., Deck J., Sutherland J., Li Z., Walters M., Duran N., Holman M., and Foley S.
Appl Enivron Microbiol. 2016, 82(20):6273-6283.
 

Molecular Characterization of Salmonella enterica Serovars Isolated from a Turkey Production Facility in the Absence of Selective Antimicrobial Pressure.
Sanad Y., Johnson K., Park S., Han J., Deck J., Foley S., Kenney B., Ricke S., and Nayak R.
Foodborne Path Dis. 2016, 13(2):80-87.
 

Evaluation of Virulence and Antimicrobial Resistance in Salmonella Enterica Serovar Enteritidis Isolates from Humans and Chicken- and Egg-associated Sources.
Han J., Gokulan K., Barnette D., Khare S., Rooney A., Deck J., Nayak R., Stefanova R., Hart M., and Foley S.
Foodborne Path Dis. 2013, 10(12):1008-1015.
 

Impact of Plasmids, Including those Encoding VirB4/D4 Type IV Secretion Systems on Salmonella Enterica serovar Heidelberg Virulence in Macrophages and Epithelial Cells.
Gokulan K., Han J., Khare S., Rooney A., Lynne A., and Foley S.
PLoS One. 2013, 8(10):e77866.
 

The Contribution of ArsB to Arsenic Resistance in Campylobacter Jejuni.
Shen Z., Han J., Wang Y., Sahin O., and Zhang Q.
PLoS One. 2013, 8(3):e58894.
 

DNA Sequence Analysis of Multidrug Resistance Encoding Plasmids from Salmonella Enterica Serotype Heidelberg Isolates.
Han J., Lynne A., David D., Tang H., Xu J., Nayak R., Kaldhone P., Logue C., and Foley S. 
PLoS One. 2012, 7(12):e51160.
 

Prevalence of ESBLs and PMQR Genes in Fecal Escherichia Coli Isolated from the Non-human Primates in Six Zoos in China.
Wang Y., He T., Han J., Wang J., Foley S., Yang G., Wan S., Shen J., and Wu C.
Vet Microbiol. 2012, 159(1-2):53-9.
 

Genetic Characterization of Antimicrobial Resistance in Salmonella Enterica Serovars Isolated from Dairy Cattle in Wisconsin.
Marrero-Ortiz R., Han J., Lynne A., Stemper M., David D., Nayak R., and Foley SL.
Food Res Int. 2012, 45(2):962-967.
 

Sequencing of Plasmids from a Multi-antimicrobial Resistant Salmonella enterica serovar Dublin Strain.
Han J., Lynne A., David D., and Foley SL.
Food Res Int. 2012, 45(2):931-934.
 

Characterization of Antimicrobial Resistance in Salmonella Enterica Serovar Typhimurium Isolates from Food Animals in the U.S.
Louden B., Haarman D., Han J., Foley S., and Lynne A.
Food Res Int. 2012, 45(2):968-972.
 

A Fluoroquinolone Resistance Associated Mutation in GyrA Affects DNA Supercoiling in Campylobacter Jejuni. 
Han J., Wang Y., Sahin O., Shen Z., Guo B., Shen J., and Zhang Q.
Front Cell Infect Microbiol. 2012, 2:21
 

Population Dynamics of Salmonella Enterica Serotypes in Commercial Egg and Poultry Production.
Foley S., Nayak R., Hanning I., Johnson T., Han J., and Ricke S.
Appl Environ Microbiol. 2011, 77(13):4273-4279.
 

The New Genetic Environment of cfr on Plasmid pBS-02 in a Bacillus Strain.
Zhang W., Wu C., Wang Y., Shen Z., Dai L., Han J., Foley S., Shen J., and Zhang Q.
J Antimicrob Chemother. 2011, 66(5):1174-5.
 

Comparison of Salmonella Enterica Serovar Heidelberg Isolated from Human Patients with Those from Animal and Food Sources. 
Han J., David D., Deck J., Lynne A., Kaldhone P., Nayak R., Stefanova R., and Foley S.
J Clin Microbiol. 2011, 49(3):1130-33.
 

Microarray Analysis of Virulence Gene Profiles in Salmonella serovars from Food/Food Animal Environment.
Zou W., Al-Khaldi S., Branham W., Han T., Fuscoe J., Han J., Foley S., Xu J., Fang H., Cerniglia C., and Nayak R.
J Infect Dev Ctries. 2011, 5(2):94-105.
 

Horizontal Gene Transfer has Resulted in a Dominant Avian Clonal Type of Salmonella Enterica Serovar Kentucky.
Johnson T., Thorsness J., Anderson C., Lynne A., Foley S., Han J., Fricke W., McDermott P., White D., Khatri M., Stell A., Flores C., and Singer R.
PLoS One. 2010, 5(12):e15524
 

Salmonella enterica Isolates from Pasture-raised Poultry Exhibit Antimicrobial Resistance and Class I Integrons.
Melendez S., Hanning I., Han J., Nayak R., Clement A., Wooming A., Hererra P., Jones F., Foley S., and Ricke S.
J Appl Microbiol. 2010, 109(6):1957-66. 
 

Evaluation of a Virulence Factor Profiling in the Characterization of Veterinary Escherichia coli. 
David D., Lynne A., Han J., and Foley S.
Appl Environ Microbiol. 2010, 76(22):7509-7513.
 

Antibiotic Resistance in Campylobacter: Emergence, Transmission and Persistence.
Luangtongkum T., Jeon B., Han J., Plummer P., Logue C., and Zhang Q.
Future Microbiol. 2009, 4(2):189-200.
 

Key Role of Mfd in the Development of Fluoroquinolone Resistance in Campylobacter Jejuni.  
Han J., Sahin O., Barton Y., and Zhang Q.
PLoS Pathog. 2008, 4(6):e1000083.