Title of the Review:     

External Peer Review of the Expanded Decision Tree: Ranking Toxic Potential

Tentative Assessment:    

Highly Influential Scientific Information

Agency Contact:         

Szabina Stice

Office or Center:         

Center for Food Safety and Applied Nutrition

Subject of the Review:    

The Expanded Decision Tree (EDT), a screening tool that would provide a consistent, systematic, science-based approach to help prioritize chemicals for evaluation.  The EDT is a modernized version of the original Cramer Decision Tree. 

Purpose of the Review:    

To solicit comments and feedback on FDA’s approach on the development of the EDT.

Type of Review:        

Individual Reviews (Letter Review) 

Timing of Review:        

Spring/Summer 2024

Number of Reviewers:    

4-6

Primary Disciplines/Types of Expertise of Reviewers:     

Organic chemistry; structure-toxicity relationships; read-across; Cramer Decision Tree (1978); Threshold of Toxicological concern concept

Reviewers Selected by:    

Designated Outside Organization.

Opportunities for the Public to Comment:     

No.

If yes, briefly state how and when will these opportunities be provided: 

N/a.

Peer Reviewers Provided with Public Comments:     

No.