AURA3: Bruising

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In AURA3 Study, Patients Were Asked: "In the last 7 days, did you BRUISE EASILY (BLACK AND BLUE MARKS)?"

Patients reported the occurrence of their Bruising on a 2-point scale (No, Yes)

Patient-Reported Bruising During the First 24 Weeks on Treatment for Patients Who Completed a Questionnaire:

Figure 1 shows the percentage of patients reporting if they had Bruising at each time point. For example, at week 2, 11% of patients taking Tagrisso reported Bruising. The range of patients who had any Bruising during the first 24 weeks of treatment with Tagrisso was between 9% - 21%. Click here for more information on how to read the graphs below.

Figure 1. Patient-Reported Bruising During the First 24 Weeks on Treatment

Two stacked bar charts, one for Tagrisso and the other for chemotherapy, showing proportion of patients reporting the occurrence of bruising at each time point through the first 24 weeks of treatment. For example, at week 2, 11% of patients taking Tagrisso reported an occurrence of bruising.

All responses from patients' experiences just before and up to week 24 on-treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.

Any Bruising Occurrence That Patients Reported During the First 24 Weeks on Treatment

Figure 2. Any Patient-Reported Bruising During the First 24 Weeks on Treatment

Two pie charts, one for Tagrisso and the other for chemotherapy, summarizing the percentage of patients who reported any bruising during the first 24 weeks of the clinical trial. In the Tagrisso arm, No (58%), and Yes (42%). In the chemotherapy arm, No (45%) and Yes (55%).

Patients with at least one on-treatment Bruising score were included in the analysis. Tagrisso (N=99), Chemotherapy (N=55).

Some Patients Did Not Report Bruising Before Treatment:

For patients that did not report Bruising before treatment, Figure 3 shows the percentage of patients reporting if they had Bruising between weeks 1 and 24.

Figure 3. Patient-Reported Bruising During the First 24 Weeks on Treatment: Patients Without Bruising Before Treatment

Two stacked bar charts, one for Tagrisso and the other for chemotherapy, which includes only those patients who had no bruising before treatment. The bar charts show the proportion of patients reporting occurrence of bruising at each time point through 24 weeks. For example, at week 2, 4% of patients taking Tagrisso reported an occurrence of bruising.

All responses from patients who did not report Bruising before treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.

Any Bruising Occurrence That Patients Reported During the First 24 Weeks on Treatment, for Patients Who Did Not Have Bruising Before Treatment:

Figure 4. Any Patient-Reported Bruising During the First 24 Weeks on Treatment: Patients Without Bruising Before Treatment

Two pie charts, one for Tagrisso and the other for chemotherapy, which includes only those patients who had no bruising before treatment. The pie charts summarize the percentage of patients who reported any bruising. In the Tagrisso arm, No (65%) and Yes (35%). In the chemotherapy arm, No (59%) and Yes (41%).

Patients who had no Bruising before treatment and at least one on-treatment Bruising score were included in the analysis. Tagrisso (N=75), Chemotherapy (N=34).